The danger model: a renewed sense of self. Export

@article{citeulike:594772, abstract = {For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.}, address = {Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. pcm@helix.nih.gov}, author = {Matzinger, P.}, citeulike-article-id = {594772}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1071059}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/296/5566/301}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11951032}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11951032}, day = {12}, doi = {10.1126/science.1071059}, issn = {1095-9203}, journal = {Science}, keywords = {immunology}, month = {April}, number = {5566}, pages = {301--305}, posted-at = {2006-04-21 22:08:34}, priority = {5}, title = {The danger model: a renewed sense of self.}, url = {http://dx.doi.org/10.1126/science.1071059}, volume = {296}, year = {2002} }

TY - JOUR ID - citeulike:594772 L3 - citeulike-article-id:594772 N2 - For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign. IS - 5566 JF - Science SN - 1095-9203 AD - Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. pcm@helix.nih.gov EP - 305 TI - The danger model: a renewed sense of self. VL - 296 SP - 301 KW - immunology AU - Matzinger, P PY - 2002/04/12/ UR - http://dx.doi.org/10.1126/science.1071059 ER -