Single-molecule DNA sequencing technologies for future genomics research

@article{citeulike:3170121, abstract = {During the current genomics revolution, the genomes of a large number of living organisms have been fully sequenced. However, with the advent of new sequencing technologies, genomics research is now at the threshold of a second revolution. Several second-generation sequencing platforms became available in 2007, but a further revolution in DNA resequencing technologies is being witnessed in 2008, with the launch of the first single-molecule DNA sequencer (Helicos Biosciences), which has already been used to resequence the genome of the M13 virus. This review discusses several single-molecule sequencing technologies that are expected to become available during the next few years and explains how they might impact on genomics research.}, author = {Gupta, Pushpendra K.}, citeulike-article-id = {3170121}, doi = {10.1016/j.tibtech.2008.07.003}, journal = {Trends in Biotechnology}, keywords = {advances, dna, helicos, molecule, sequencing, single, technology}, posted-at = {2008-08-28 18:42:45}, priority = {2}, title = {Single-molecule DNA sequencing technologies for future genomics research}, url = {http://dx.doi.org/10.1016/j.tibtech.2008.07.003}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:3170121 L3 - citeulike-article-id:3170121 N2 - During the current genomics revolution, the genomes of a large number of living organisms have been fully sequenced. However, with the advent of new sequencing technologies, genomics research is now at the threshold of a second revolution. Several second-generation sequencing platforms became available in 2007, but a further revolution in DNA resequencing technologies is being witnessed in 2008, with the launch of the first single-molecule DNA sequencer (Helicos Biosciences), which has already been used to resequence the genome of the M13 virus. This review discusses several single-molecule sequencing technologies that are expected to become available during the next few years and explains how they might impact on genomics research. JF - Trends in Biotechnology TI - Single-molecule DNA sequencing technologies for future genomics research VL - In Press, Corrected Proof KW - advances KW - dna KW - helicos KW - molecule KW - sequencing KW - single KW - technology AU - Gupta, Pushpendra UR - http://dx.doi.org/10.1016/j.tibtech.2008.07.003 ER -