Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men Export

@article{citeulike:3768437, abstract = {OBJECTIVE--To understand why atherogenic risk differs more between diabetic and nondiabetic women than between diabetic and nondiabetic men. RESEARCH DESIGN AND METHODS AND RESULTS--Measures of cardiovascular risk, body composition, and serum hormones from the baseline examinations of the Insulin Resistance Atherosclerosis Study on 524 nondiabetic women, 258 diabetic women, 421 nondiabetic men, and 220 diabetic men were compared to detect greater adverse differences in women than in men. Systolic blood pressure; apolipoprotein B (apoB); total cholesterol; apoB-to-apoA-I ratio; non-HDL cholesterol; LDL particle count, small LDL, and intermediate-density lipoprotein by nuclear magnetic resonance; and C-reactive protein exhibited significant diabetes-sex interaction (P < 0.05). ApoB exhibited the most significant interaction (P = 0.0005). Age- and ethnicity-adjusted apoB means were lower in nondiabetic women than nondiabetic men (102.4 vs. 106.8 mg/dl, P < 0.05) but higher in diabetes (115.7 vs. 110.2 mg/dl, P < 0.01). Plotted against BMI, waist circumference was 6\% higher and hip circumference 10\% lower in diabetic than nondiabetic women (both P < 0.05), whereas the circumference measures did not differ conspicuously between diabetic and nondiabetic men. CONCLUSIONS--In diabetic women, an elevated level of atherogenic particles, as manifested by apoB and LDL particle count, which may result from abdominal adiposity, represents a major treatable cardiovascular risk factor. 10.2337/db08-0787}, author = {Williams, Ken and Tchernof, Andre and Hunt, Kelly J. and Wagenknecht, Lynne E. and Haffner, Steven M. and Sniderman, Allan D.}, citeulike-article-id = {3768437}, citeulike-linkout-0 = {http://dx.doi.org/10.2337/db08-0787}, citeulike-linkout-1 = {http://diabetes.diabetesjournals.org/cgi/content/abstract/57/12/3289?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18809621}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18809621}, day = {1}, doi = {10.2337/db08-0787}, journal = {Diabetes}, keywords = {abdominal, atherogenic, diabetes, dyslipoproteinemia, obesity, particle, risk, size, women}, month = {December}, number = {12}, pages = {3289--3296}, posted-at = {2008-12-10 15:54:03}, priority = {2}, title = {Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men}, url = {http://dx.doi.org/10.2337/db08-0787}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:3768437 L3 - citeulike-article-id:3768437 N2 - OBJECTIVE--To understand why atherogenic risk differs more between diabetic and nondiabetic women than between diabetic and nondiabetic men. RESEARCH DESIGN AND METHODS AND RESULTS--Measures of cardiovascular risk, body composition, and serum hormones from the baseline examinations of the Insulin Resistance Atherosclerosis Study on 524 nondiabetic women, 258 diabetic women, 421 nondiabetic men, and 220 diabetic men were compared to detect greater adverse differences in women than in men. Systolic blood pressure; apolipoprotein B (apoB); total cholesterol; apoB-to-apoA-I ratio; non-HDL cholesterol; LDL particle count, small LDL, and intermediate-density lipoprotein by nuclear magnetic resonance; and C-reactive protein exhibited significant diabetes-sex interaction (P < 0.05). ApoB exhibited the most significant interaction (P = 0.0005). Age- and ethnicity-adjusted apoB means were lower in nondiabetic women than nondiabetic men (102.4 vs. 106.8 mg/dl, P < 0.05) but higher in diabetes (115.7 vs. 110.2 mg/dl, P < 0.01). Plotted against BMI, waist circumference was 6% higher and hip circumference 10% lower in diabetic than nondiabetic women (both P < 0.05), whereas the circumference measures did not differ conspicuously between diabetic and nondiabetic men. CONCLUSIONS--In diabetic women, an elevated level of atherogenic particles, as manifested by apoB and LDL particle count, which may result from abdominal adiposity, represents a major treatable cardiovascular risk factor. 10.2337/db08-0787 IS - 12 JF - Diabetes EP - 3296 TI - Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men VL - 57 SP - 3289 KW - abdominal KW - atherogenic KW - diabetes KW - dyslipoproteinemia KW - obesity KW - particle KW - risk KW - size KW - women AU - Williams, Ken AU - Tchernof, Andre AU - Hunt, Kelly AU - Wagenknecht, Lynne AU - Haffner, Steven AU - Sniderman, Allan PY - 2008/12/01/ UR - http://dx.doi.org/10.2337/db08-0787 ER -