Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection. Export

@article{citeulike:2919250, abstract = {Enteric pathogens such as Yersinia enterocolitica readily colonize and induce disease within the lymphatic tissues of the small intestine. To gain a comprehensive view of the host response to pathogens within these tissues, we determined the transcriptional profiles of intestinal lymphatic tissue infected with Y. enterocolitica. Expression analysis using Affymetrix GeneChips revealed a complex host response in the Peyer's patches and mesenteric lymph nodes after oral infection with Y. enterocolitica. Interestingly, histidine decarboxylase (Hdc) was significantly up-regulated in response to Y. enterocolitica infection. HDC is the enzyme solely responsible for the production of the biogenic amine histamine. Although histamine is well known for its role in allergy and for its effects on immunity and inflammation, little is known about its role or specific histamine receptors during the host response to bacterial infection. In this study, we provide evidence that histamine signaling through the histamine H(2) but not the H(1) receptor is important for controlling Y. enterocolitica infection within the Peyer's patches and mesenteric lymph nodes of mice.}, address = {Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.}, author = {Handley, S. A. and Dube, P. H. and Miller, V. L.}, citeulike-article-id = {2919250}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0510414103}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16717182}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16717182}, day = {13}, doi = {10.1073/pnas.0510414103}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {enterocolitica, histamine}, month = {June}, number = {24}, pages = {9268--9273}, posted-at = {2008-06-23 17:28:16}, priority = {0}, title = {Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection.}, url = {http://dx.doi.org/10.1073/pnas.0510414103}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:2919250 L3 - citeulike-article-id:2919250 N2 - Enteric pathogens such as Yersinia enterocolitica readily colonize and induce disease within the lymphatic tissues of the small intestine. To gain a comprehensive view of the host response to pathogens within these tissues, we determined the transcriptional profiles of intestinal lymphatic tissue infected with Y. enterocolitica. Expression analysis using Affymetrix GeneChips revealed a complex host response in the Peyer's patches and mesenteric lymph nodes after oral infection with Y. enterocolitica. Interestingly, histidine decarboxylase (Hdc) was significantly up-regulated in response to Y. enterocolitica infection. HDC is the enzyme solely responsible for the production of the biogenic amine histamine. Although histamine is well known for its role in allergy and for its effects on immunity and inflammation, little is known about its role or specific histamine receptors during the host response to bacterial infection. In this study, we provide evidence that histamine signaling through the histamine H(2) but not the H(1) receptor is important for controlling Y. enterocolitica infection within the Peyer's patches and mesenteric lymph nodes of mice. IS - 24 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. EP - 9273 TI - Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection. VL - 103 SP - 9268 KW - enterocolitica KW - histamine AU - Handley, SA AU - Dube, PH AU - Miller, VL PY - 2006/06/13/ UR - http://dx.doi.org/10.1073/pnas.0510414103 ER -