Protective role of interleukin-6 during Yersinia enterocolitica infection is mediated through the modulation of inflammatory cytokines. Export

@article{citeulike:2919258, abstract = {Yersinia enterocolitica is a gram-negative enteric pathogen responsible for a number of gastrointestinal disorders. A striking feature of the pathology of a Y. enterocolitica infection is inflammation. Recently, we demonstrated a role for interleukin-1alpha (IL-1alpha) in the establishment of intestinal inflammation in response to a Y. enterocolitica infection. A cytokine directly affected by IL-1 levels is IL-6. A previous report suggested that IL-6 plays an anti-inflammatory role during Y. enterocolitica infection, and in other systems IL-6 has been shown to be proinflammatory. Therefore, a closer examination of the roles of IL-6 and inflammatory cytokines in the control of Y. enterocolitica infection in IL-6(-/-) mice was undertaken. Y. enterocolitica organisms were more virulent in the IL-6(-/-) mice (60-fold decreased 50\% lethal dose) and colonized systemic tissues more rapidly and to a higher level than in the wild-type mice. One role of IL-6 during a Y. enterocolitica infection may be the downmodulation of the inflammatory response. The IL-6(-/-) mice have a more robust T(H)1 T-cell response, as well as hyperinflammatory pathologies. These phenotypes appear to be due to the misregulation of tumor necrosis factor alpha, monocyte chemotactic protein 1, IL-10, transforming growth factor beta1, and gamma interferon in the IL-6(-/-) mouse. These data provide further insight into the intricate cytokine signaling pathways involved in the regulation of inflammatory responses and the control of bacterial infections.}, address = {Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.}, author = {Dube, P. H. and Handley, S. A. and Lewis, J. and Miller, V. L.}, citeulike-article-id = {2919258}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/IAI.72.6.3561-3570.2004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15155665}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15155665}, doi = {10.1128/IAI.72.6.3561-3570.2004}, issn = {0019-9567}, journal = {Infection and immunity}, keywords = {enterocolitica, interleukin-6}, month = {June}, number = {6}, pages = {3561--3570}, posted-at = {2008-06-23 17:30:14}, priority = {0}, title = {Protective role of interleukin-6 during Yersinia enterocolitica infection is mediated through the modulation of inflammatory cytokines.}, url = {http://dx.doi.org/10.1128/IAI.72.6.3561-3570.2004}, volume = {72}, year = {2004} }

TY - JOUR ID - citeulike:2919258 L3 - citeulike-article-id:2919258 N2 - Yersinia enterocolitica is a gram-negative enteric pathogen responsible for a number of gastrointestinal disorders. A striking feature of the pathology of a Y. enterocolitica infection is inflammation. Recently, we demonstrated a role for interleukin-1alpha (IL-1alpha) in the establishment of intestinal inflammation in response to a Y. enterocolitica infection. A cytokine directly affected by IL-1 levels is IL-6. A previous report suggested that IL-6 plays an anti-inflammatory role during Y. enterocolitica infection, and in other systems IL-6 has been shown to be proinflammatory. Therefore, a closer examination of the roles of IL-6 and inflammatory cytokines in the control of Y. enterocolitica infection in IL-6(-/-) mice was undertaken. Y. enterocolitica organisms were more virulent in the IL-6(-/-) mice (60-fold decreased 50% lethal dose) and colonized systemic tissues more rapidly and to a higher level than in the wild-type mice. One role of IL-6 during a Y. enterocolitica infection may be the downmodulation of the inflammatory response. The IL-6(-/-) mice have a more robust T(H)1 T-cell response, as well as hyperinflammatory pathologies. These phenotypes appear to be due to the misregulation of tumor necrosis factor alpha, monocyte chemotactic protein 1, IL-10, transforming growth factor beta1, and gamma interferon in the IL-6(-/-) mouse. These data provide further insight into the intricate cytokine signaling pathways involved in the regulation of inflammatory responses and the control of bacterial infections. IS - 6 JF - Infection and immunity SN - 0019-9567 AD - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. EP - 3570 TI - Protective role of interleukin-6 during Yersinia enterocolitica infection is mediated through the modulation of inflammatory cytokines. VL - 72 SP - 3561 KW - enterocolitica KW - interleukin-6 AU - Dube, PH AU - Handley, SA AU - Lewis, J AU - Miller, VL PY - 2004/06// UR - http://dx.doi.org/10.1128/IAI.72.6.3561-3570.2004 ER -