The rovA mutant of Yersinia enterocolitica displays differential degrees of virulence depending on the route of infection. Export

@article{citeulike:2919265, abstract = {Yersinia enterocolitica is an invasive enteric pathogen that causes significant inflammatory disease. Recently, we identified and characterized a global regulator of virulence (rovA). When mice are infected orally with the rovA mutant they are attenuated by 50\% lethal dose (LD(50)) analysis and have altered kinetics of infection. Most significantly, mice orally infected with the rovA mutant have greatly reduced inflammation in the Peyer's patches compared to those infected with wild-type Y. enterocolitica. However, we present data here indicating that when the rovA mutant bacteria are delivered intraperitoneally (i.p.), they are significantly more virulent than when delivered orally. The i.p. LD(50) for the rovA mutant is only 10-fold higher than that of the wild-type Y. enterocolitica, and there are significant inflammatory responses to the rovA mutant that are evident in the liver and spleen. Altogether, these data suggest that the RovA regulon may be required for the early events of the infection that occur in the Peyer's patches. Furthermore, these data suggest that the RovA regulon may be dispensable for Y. enterocolitica systemic disease and inflammatory responses if the Peyer's patches are bypassed.}, address = {Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.}, author = {Dube, P. H. and Handley, S. A. and Revell, P. A. and Miller, V. L.}, citeulike-article-id = {2919265}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12761136}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12761136}, issn = {0019-9567}, journal = {Infection and immunity}, keywords = {enterocolitica}, month = {June}, number = {6}, pages = {3512--3520}, posted-at = {2008-06-23 17:32:02}, priority = {0}, title = {The rovA mutant of Yersinia enterocolitica displays differential degrees of virulence depending on the route of infection.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12761136}, volume = {71}, year = {2003} }

TY - JOUR ID - citeulike:2919265 L3 - citeulike-article-id:2919265 N2 - Yersinia enterocolitica is an invasive enteric pathogen that causes significant inflammatory disease. Recently, we identified and characterized a global regulator of virulence (rovA). When mice are infected orally with the rovA mutant they are attenuated by 50% lethal dose (LD(50)) analysis and have altered kinetics of infection. Most significantly, mice orally infected with the rovA mutant have greatly reduced inflammation in the Peyer's patches compared to those infected with wild-type Y. enterocolitica. However, we present data here indicating that when the rovA mutant bacteria are delivered intraperitoneally (i.p.), they are significantly more virulent than when delivered orally. The i.p. LD(50) for the rovA mutant is only 10-fold higher than that of the wild-type Y. enterocolitica, and there are significant inflammatory responses to the rovA mutant that are evident in the liver and spleen. Altogether, these data suggest that the RovA regulon may be required for the early events of the infection that occur in the Peyer's patches. Furthermore, these data suggest that the RovA regulon may be dispensable for Y. enterocolitica systemic disease and inflammatory responses if the Peyer's patches are bypassed. IS - 6 JF - Infection and immunity SN - 0019-9567 AD - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. EP - 3520 TI - The rovA mutant of Yersinia enterocolitica displays differential degrees of virulence depending on the route of infection. VL - 71 SP - 3512 KW - enterocolitica AU - Dube, PH AU - Handley, SA AU - Revell, PA AU - Miller, VL PY - 2003/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/12761136 ER -