Sir2 blocks extreme life-span extension Export

@article{RefWorks:19, abstract = {Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span, and increasing Sir2 dosage can delay replicative aging. We address the role of Sir2 in regulating chronological life span in yeast. Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological life-span extension. Inactivation of Sir2 causes uptake and catabolism of ethanol and upregulation of many stress-resistance and sporulation genes. These changes while sufficient to extend chronological life span in wild-type yeast require severe calorie restriction or additional mutations to extend life span of sir2Delta mutants. Our results demonstrate that effects of SIR2 on chronological life span are opposite to replicatve life span and suggest that the relevant activities of Sir2-like deacetylases may also be complex in higher eukaryotes.}, author = {Fabrizio, P. and Gattazzo, C. and Battistella, L. and Wei, M. and Cheng, C. and Mcgrew, K. and Longo, V. D.}, citeulike-article-id = {1080660}, journal = {Cell}, keywords = {3pharmacology, adenylate, alcohol, bibtex-import, biological, cerevisiae, cerevisiaedrug, cerevisiaegeneticsphysiology, chemical, cyclasegenetics, deacetylasesgeneticsphysiology, dehydrogenasemetabolism, deletion, dna, down-regulationgenetics, effectsgeneticsphysiology, ethanolmetabolismpharmacology, expression, extramural, factors, fungalgenetics, gene, genomics, govt, heat, histone, hydrogen, information, k, kinasesgenetics, models, mutationgenetics, nih, non-us, oxidative, peroxidepharmacology, profiling, protein, proteins, proteinsgeneticsphysiology, regulation, regulator, repair, research, saccharomyces, silent, sirtuinsgeneticsphysiology, stress, support, time, up-regulationgenetics, vitamin}, month = {Nov}, number = {4}, pages = {655--667}, posted-at = {2007-01-31 19:05:18}, priority = {0}, title = {Sir2 blocks extreme life-span extension}, volume = {123}, year = {2005} }

TY - JOUR ID - RefWorks:19 L3 - citeulike-article-id:1080660 N2 - Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span, and increasing Sir2 dosage can delay replicative aging. We address the role of Sir2 in regulating chronological life span in yeast. Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological life-span extension. Inactivation of Sir2 causes uptake and catabolism of ethanol and upregulation of many stress-resistance and sporulation genes. These changes while sufficient to extend chronological life span in wild-type yeast require severe calorie restriction or additional mutations to extend life span of sir2Delta mutants. Our results demonstrate that effects of SIR2 on chronological life span are opposite to replicatve life span and suggest that the relevant activities of Sir2-like deacetylases may also be complex in higher eukaryotes. IS - 4 JF - Cell EP - 667 TI - Sir2 blocks extreme life-span extension VL - 123 SP - 655 KW - 3pharmacology KW - adenylate KW - alcohol KW - bibtex-import KW - biological KW - cerevisiae KW - cerevisiaedrug KW - cerevisiaegeneticsphysiology KW - chemical KW - cyclasegenetics KW - deacetylasesgeneticsphysiology KW - dehydrogenasemetabolism KW - deletion KW - dna KW - down-regulationgenetics KW - effectsgeneticsphysiology KW - ethanolmetabolismpharmacology KW - expression KW - extramural KW - factors KW - fungalgenetics KW - gene KW - genomics KW - govt KW - heat KW - histone KW - hydrogen KW - information KW - k KW - kinasesgenetics KW - models KW - mutationgenetics KW - nih KW - non-us KW - oxidative KW - peroxidepharmacology KW - profiling KW - protein KW - proteins KW - proteinsgeneticsphysiology KW - regulation KW - regulator KW - repair KW - research KW - saccharomyces KW - silent KW - sirtuinsgeneticsphysiology KW - stress KW - support KW - time KW - up-regulationgenetics KW - vitamin AU - Fabrizio, P AU - Gattazzo, C AU - Battistella, L AU - Wei, M AU - Cheng, C AU - Mcgrew, K AU - Longo, VD PY - 2005/Nov 18// ER -