A microRNA component of the p53 tumour suppressor network. Export

@article{citeulike:1369603, abstract = {A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation.}, author = {He, Lin and He, Xingyue and Lim, Lee P. and de Stanchina, Elisa and Xuan, Zhenyu and Liang, Yu and Xue, Wen and Zender, Lars and Magnus, Jill and Ridzon, Dana and Jackson, Aimee L. and Linsley, Peter S. and Chen, Caifu and Lowe, Scott W. and Cleary, Michele A. and Hannon, Gregory J.}, citeulike-article-id = {1369603}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature05939}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature05939}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17554337}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17554337}, day = {28}, doi = {10.1038/nature05939}, issn = {1476-4687}, journal = {Nature}, keywords = {networkphysics}, month = {June}, number = {7148}, pages = {1130--1134}, posted-at = {2007-06-10 02:17:08}, priority = {4}, publisher = {Nature Publishing Group}, title = {A microRNA component of the p53 tumour suppressor network.}, url = {http://dx.doi.org/10.1038/nature05939}, volume = {447}, year = {2007} }

TY - JOUR ID - citeulike:1369603 L3 - citeulike-article-id:1369603 N2 - A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to downregulate a programme of genes promoting cell cycle progression. The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation. IS - 7148 JF - Nature SN - 1476-4687 EP - 1134 TI - A microRNA component of the p53 tumour suppressor network. PB - Nature Publishing Group VL - 447 SP - 1130 KW - networkphysics AU - He, Lin AU - He, Xingyue AU - Lim, Lee AU - de Stanchina, Elisa AU - Xuan, Zhenyu AU - Liang, Yu AU - Xue, Wen AU - Zender, Lars AU - Magnus, Jill AU - Ridzon, Dana AU - Jackson, Aimee AU - Linsley, Peter AU - Chen, Caifu AU - Lowe, Scott AU - Cleary, Michele AU - Hannon, Gregory PY - 2007/06/28/ UR - http://dx.doi.org/10.1038/nature05939 ER -