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Genome Research, Vol. 22, No. 11. (01 November 2012), pp. 2120-2129, doi:10.1101/gr.137596.112 Key: citeulike:11599108
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An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
Just for reference purposes: how people identify and test actionable mutaitons in cancer. They used two functional effect prediction tools (CHASM and MutationAssessor), may be interesting to look at them. Identified set of mutation with potential functional impact and tested them in vivo using cell lines (either siRNA or overexpression of corresponding mutant gene with measurement of phenotypic effect)
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