The Effect of Blockade of Tumor Necrosis Factor alpha on VLA-1+T-Cells in Rheumatoid Arthritis Patients. Export

@article{citeulike:1695631, abstract = {The alpha1beta1 integrin, very late antigen (VLA)-1, characterizes collagen adherent interferon (IFN) gamma producing memory T cells in inflamed synovium. We now report that the mean percentage of VLA-1+ T cells is significantly lower among peripheral blood mononuclear cells of rheumatoid patients responsive to antitumor necrosis factor (TNF) alpha therapy than of those with active disease not receiving therapy. Neutralization of TNFalpha during in vitro polyclonal activation of VLA-1- T cells reduced differentiation to expression of VLA-1 and inhibited secretion of IFNgamma, but did not affect integrin expression on in vivo differentiated VLA-1+ T cells. Moreover, synovial fluids of patients relapsing during and after therapy were enriched in VLA-1+ T cells and lines derived from VLA-1+ T cells in peripheral blood of treated patients retained collagen binding and secreted IFN gamma. Thus, whereas therapy decreases VLA-1+ T cells in rheumatoid arthritis patients, a subset is resistant and contributes to residual and recurring inflammation.}, address = {Medicine and Laboratory for Immunoregulation, Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel.}, author = {Bank, Ilan and Ben-Horin, Shomron and Goldstein, Itamar and Koltakov, Alexander and Langevitz, Pnina and Ehrenfeld, Michael and Rosenthal, Esther and Gur, Hanan}, citeulike-article-id = {1695631}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s10875-007-9119-6}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17891451}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17891451}, day = {22}, doi = {10.1007/s10875-007-9119-6}, issn = {0271-9142}, journal = {J Clin Immunol}, keywords = {arthritis, vla-1}, month = {September}, posted-at = {2007-09-26 01:38:21}, priority = {2}, title = {The Effect of Blockade of Tumor Necrosis Factor alpha on VLA-1+T-Cells in Rheumatoid Arthritis Patients.}, url = {http://dx.doi.org/10.1007/s10875-007-9119-6}, year = {2007} }

TY - JOUR ID - citeulike:1695631 L3 - citeulike-article-id:1695631 N2 - The alpha1beta1 integrin, very late antigen (VLA)-1, characterizes collagen adherent interferon (IFN) gamma producing memory T cells in inflamed synovium. We now report that the mean percentage of VLA-1+ T cells is significantly lower among peripheral blood mononuclear cells of rheumatoid patients responsive to antitumor necrosis factor (TNF) alpha therapy than of those with active disease not receiving therapy. Neutralization of TNFalpha during in vitro polyclonal activation of VLA-1- T cells reduced differentiation to expression of VLA-1 and inhibited secretion of IFNgamma, but did not affect integrin expression on in vivo differentiated VLA-1+ T cells. Moreover, synovial fluids of patients relapsing during and after therapy were enriched in VLA-1+ T cells and lines derived from VLA-1+ T cells in peripheral blood of treated patients retained collagen binding and secreted IFN gamma. Thus, whereas therapy decreases VLA-1+ T cells in rheumatoid arthritis patients, a subset is resistant and contributes to residual and recurring inflammation. JF - J Clin Immunol SN - 0271-9142 AD - Medicine and Laboratory for Immunoregulation, Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel. TI - The Effect of Blockade of Tumor Necrosis Factor alpha on VLA-1+T-Cells in Rheumatoid Arthritis Patients. KW - arthritis KW - vla-1 AU - Bank, Ilan AU - Ben-Horin, Shomron AU - Goldstein, Itamar AU - Koltakov, Alexander AU - Langevitz, Pnina AU - Ehrenfeld, Michael AU - Rosenthal, Esther AU - Gur, Hanan PY - 2007/09/22/ UR - http://dx.doi.org/10.1007/s10875-007-9119-6 ER -