T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Export

@article{citeulike:2399428, abstract = {After homing to lymph nodes, CD8(+) T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinetics correlated inversely with the number of complexes of cognate peptide and major histocompatibility complex (pMHC) per DC and with the density of antigen-presenting DCs per lymph node. Very few pMHC complexes were necessary for the induction of full-fledged T cell activation and effector differentiation. However, neither T cell activation nor transition to phase two occurred below a threshold antigen dose determined in part by pMHC stability. Thus, phase one permits T cells to make integrated 'measurements' of antigen dose that determine subsequent T cell participation in immune responses.}, address = {Department of Pathology and the Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.}, author = {Henrickson, Sarah E E. and Mempel, Thorsten R R. and Mazo, Irina B B. and Liu, Bai and Artyomov, Maxim N N. and Zheng, Huan and Peixoto, Antonio and Flynn, Michael P P. and Senman, Balimkiz and Junt, Tobias and Wong, Hing C C. and Chakraborty, Arup K K. and von Andrian, Ulrich H H.}, citeulike-article-id = {2399428}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ni1559}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ni1559}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18204450}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18204450}, day = {20}, doi = {10.1038/ni1559}, issn = {1529-2916}, journal = {Nat Immunol}, keywords = {imaging}, month = {January}, posted-at = {2008-02-19 16:55:32}, priority = {2}, title = {T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.}, url = {http://dx.doi.org/10.1038/ni1559}, year = {2008} }

TY - JOUR ID - citeulike:2399428 L3 - citeulike-article-id:2399428 N2 - After homing to lymph nodes, CD8(+) T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinetics correlated inversely with the number of complexes of cognate peptide and major histocompatibility complex (pMHC) per DC and with the density of antigen-presenting DCs per lymph node. Very few pMHC complexes were necessary for the induction of full-fledged T cell activation and effector differentiation. However, neither T cell activation nor transition to phase two occurred below a threshold antigen dose determined in part by pMHC stability. Thus, phase one permits T cells to make integrated 'measurements' of antigen dose that determine subsequent T cell participation in immune responses. JF - Nat Immunol SN - 1529-2916 AD - Department of Pathology and the Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. TI - T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. KW - imaging AU - Henrickson, Sarah E AU - Mempel, Thorsten R AU - Mazo, Irina B AU - Liu, Bai AU - Artyomov, Maxim N AU - Zheng, Huan AU - Peixoto, Antonio AU - Flynn, Michael P AU - Senman, Balimkiz AU - Junt, Tobias AU - Wong, Hing C AU - Chakraborty, Arup K AU - von Andrian, Ulrich H PY - 2008/01/20/ UR - http://dx.doi.org/10.1038/ni1559 ER -