Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment Export

@article{citeulike:3517323, abstract = {Leukocyte recruitment to sites of infection or inflammation requires multiple adhesive events. Although numerous players promoting leukocyte-endothelial interactions have been characterized, functionally important endogenous inhibitors of leukocyte adhesion have not been identified. Here we describe the endothelially derived secreted molecule Del-1 (developmental endothelial locus-1) as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Endothelial Del-1 deficiency increased LFA-1-dependent leukocyte adhesion in vitro and in vivo. Del-1-/- mice displayed significantly higher neutrophil accumulation in lipopolysaccharide-induced lung inflammation in vivo, which was reversed in Del-1/LFA-1 double-deficient mice. Thus, Del-1 is an endogenous inhibitor of inflammatory cell recruitment and could provide a basis for targeting leukocyte-endothelial interactions in disease. 10.1126/science.1165218}, author = {Choi, Eun Y. and Chavakis, Emmanouil and Czabanka, Marcus A. and Langer, Harald F. and Fraemohs, Line and Economopoulou, Matina and Kundu, Ramendra K. and Orlandi, Alessia and Zheng, Ying Y. and Prieto, Darue A. and Ballantyne, Christie M. and Constant, Stephanie L. and Aird, William C. and Papayannopoulou, Thalia and Gahmberg, Carl G. and Udey, Mark C. and Vajkoczy, Peter and Quertermous, Thomas and Dimmeler, Stefanie and Weber, Christian and Chavakis, Triantafyllos}, citeulike-article-id = {3517323}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1165218}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/322/5904/1101}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19008446}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19008446}, doi = {10.1126/science.1165218}, journal = {Science}, keywords = {lfa-1, migration}, month = {November}, number = {5904}, pages = {1101--1104}, posted-at = {2008-11-14 22:49:15}, priority = {2}, title = {Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment}, url = {http://dx.doi.org/10.1126/science.1165218}, volume = {322}, year = {2008} }

TY - JOUR ID - citeulike:3517323 L3 - citeulike-article-id:3517323 N2 - Leukocyte recruitment to sites of infection or inflammation requires multiple adhesive events. Although numerous players promoting leukocyte-endothelial interactions have been characterized, functionally important endogenous inhibitors of leukocyte adhesion have not been identified. Here we describe the endothelially derived secreted molecule Del-1 (developmental endothelial locus-1) as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Endothelial Del-1 deficiency increased LFA-1-dependent leukocyte adhesion in vitro and in vivo. Del-1-/- mice displayed significantly higher neutrophil accumulation in lipopolysaccharide-induced lung inflammation in vivo, which was reversed in Del-1/LFA-1 double-deficient mice. Thus, Del-1 is an endogenous inhibitor of inflammatory cell recruitment and could provide a basis for targeting leukocyte-endothelial interactions in disease. 10.1126/science.1165218 IS - 5904 JF - Science EP - 1104 TI - Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment VL - 322 SP - 1101 KW - lfa-1 KW - migration AU - Choi, Eun AU - Chavakis, Emmanouil AU - Czabanka, Marcus AU - Langer, Harald AU - Fraemohs, Line AU - Economopoulou, Matina AU - Kundu, Ramendra AU - Orlandi, Alessia AU - Zheng, Ying AU - Prieto, Darue AU - Ballantyne, Christie AU - Constant, Stephanie AU - Aird, William AU - Papayannopoulou, Thalia AU - Gahmberg, Carl AU - Udey, Mark AU - Vajkoczy, Peter AU - Quertermous, Thomas AU - Dimmeler, Stefanie AU - Weber, Christian AU - Chavakis, Triantafyllos PY - 2008/11/14/ UR - http://dx.doi.org/10.1126/science.1165218 ER -