Developmental Control of Integrin Expression Regulates Th2 Effector Homing Export

@article{citeulike:3824737, abstract = {Integrin CD18, a component of the LFA-1 complex that also includes CD11a, is essential for Th2, but not Th1, cell homing, but the explanation for this phenomenon remains obscure. In this study, we investigate the mechanism by which Th2 effector responses require the LFA-1 complex. CD11a-deficient T cells showed normal in vitro differentiation and function. However, Th2 cell-dependent allergic lung disease was markedly reduced in CD11a null mice and wild-type mice given LFA-1 inhibitors, whereas control of infection with Leishmania major, a Th1-dependent response, was enhanced. In both disease models, recruitment of IL-4-, but not IFN-{gamma}-secreting cells to relevant organs was impaired, as was adhesion of Th2 cells in vitro. These diverse findings were explained by the markedly reduced expression of CD29, an alternate homing integrin, on Th2, but not Th1, cells, which precludes Th2 homing in the absence of CD11a. Thus, murine Th1 and Th2 cells use distinct integrins for homing, suggesting novel opportunities for integrin-based therapeutic intervention in diverse human ailments influenced by Th2 cells.}, author = {Lee, Seung-Hyo and Prince, Joseph E. and Rais, Muhammad and Kheradmand, Farrah and Ballantyne, Christie M. and Weitz-Schmidt, Gabriele and Smith, Wayne C. and Corry, David B.}, citeulike-article-id = {3824737}, citeulike-linkout-0 = {http://www.jimmunol.org/cgi/content/abstract/180/7/4656?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=180&firstpage=4656&resourcetype=HWCIT}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18354189}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18354189}, day = {1}, journal = {J Immunol}, keywords = {beta1, integrin, lfa-1, th1th2}, month = {April}, number = {7}, pages = {4656--4667}, posted-at = {2008-12-26 19:39:12}, priority = {2}, title = {Developmental Control of Integrin Expression Regulates Th2 Effector Homing}, url = {http://www.jimmunol.org/cgi/content/abstract/180/7/4656?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=180&firstpage=4656&resourcetype=HWCIT}, volume = {180}, year = {2008} }

TY - JOUR ID - citeulike:3824737 L3 - citeulike-article-id:3824737 N2 - Integrin CD18, a component of the LFA-1 complex that also includes CD11a, is essential for Th2, but not Th1, cell homing, but the explanation for this phenomenon remains obscure. In this study, we investigate the mechanism by which Th2 effector responses require the LFA-1 complex. CD11a-deficient T cells showed normal in vitro differentiation and function. However, Th2 cell-dependent allergic lung disease was markedly reduced in CD11a null mice and wild-type mice given LFA-1 inhibitors, whereas control of infection with Leishmania major, a Th1-dependent response, was enhanced. In both disease models, recruitment of IL-4-, but not IFN-{gamma}-secreting cells to relevant organs was impaired, as was adhesion of Th2 cells in vitro. These diverse findings were explained by the markedly reduced expression of CD29, an alternate homing integrin, on Th2, but not Th1, cells, which precludes Th2 homing in the absence of CD11a. Thus, murine Th1 and Th2 cells use distinct integrins for homing, suggesting novel opportunities for integrin-based therapeutic intervention in diverse human ailments influenced by Th2 cells. IS - 7 JF - J Immunol EP - 4667 TI - Developmental Control of Integrin Expression Regulates Th2 Effector Homing VL - 180 SP - 4656 KW - beta1 KW - integrin KW - lfa-1 KW - th1th2 AU - Lee, Seung-Hyo AU - Prince, Joseph AU - Rais, Muhammad AU - Kheradmand, Farrah AU - Ballantyne, Christie AU - Weitz-Schmidt, Gabriele AU - Smith, Wayne AU - Corry, David PY - 2008/04/01/ UR - http://www.jimmunol.org/cgi/content/abstract/180/7/4656?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=180&firstpage=4656&resourcetype=HWCIT ER -