CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Export

@article{citeulike:5381931, abstract = {During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we demonstrate that IL-4-expressing CD4(+) T lymphocytes indirectly promote invasion and subsequent metastasis of mammary adenocarcinomas by directly regulating the phenotype and effector function of tumor-associated CD11b(+)Gr1(-)F4/80(+) macrophages that in turn enhance metastasis through activation of epidermal growth factor receptor signaling in malignant mammary epithelial cells. Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior.}, author = {DeNardo, David G. and Barreto, Jairo B. and Andreu, Pauline and Vasquez, Lesley and Tawfik, David and Kolhatkar, Nikita and Coussens, Lisa M.}, citeulike-article-id = {5381931}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2009.06.018}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1535610809002165}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19647220}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19647220}, day = {4}, doi = {10.1016/j.ccr.2009.06.018}, issn = {1878-3686}, journal = {Cancer cell}, keywords = {8012, cancer, macrophage}, month = {August}, number = {2}, pages = {91--102}, posted-at = {2009-09-30 17:55:27}, priority = {2}, title = {CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.}, url = {http://dx.doi.org/10.1016/j.ccr.2009.06.018}, volume = {16}, year = {2009} }

TY - JOUR ID - citeulike:5381931 L3 - citeulike-article-id:5381931 N2 - During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we demonstrate that IL-4-expressing CD4(+) T lymphocytes indirectly promote invasion and subsequent metastasis of mammary adenocarcinomas by directly regulating the phenotype and effector function of tumor-associated CD11b(+)Gr1(-)F4/80(+) macrophages that in turn enhance metastasis through activation of epidermal growth factor receptor signaling in malignant mammary epithelial cells. Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior. IS - 2 JF - Cancer cell SN - 1878-3686 EP - 102 TI - CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. VL - 16 SP - 91 KW - 8012 KW - cancer KW - macrophage AU - DeNardo, David AU - Barreto, Jairo AU - Andreu, Pauline AU - Vasquez, Lesley AU - Tawfik, David AU - Kolhatkar, Nikita AU - Coussens, Lisa PY - 2009/08/04/ UR - http://dx.doi.org/10.1016/j.ccr.2009.06.018 ER -