Stromal cell contributions to the homeostasis and functionality of the immune system Export

@article{citeulike:5637873, abstract = {A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the effective development of adaptive immune responses take place. What has only recently been recognized is the role that non-haematopoietic stromal elements have in many aspects of immune cell migration, activation and survival. In this Review, we summarize our current understanding of lymphoid compartment stromal cells, examine their possible heterogeneity, discuss how these cells contribute to immune homeostasis and the efficient initiation of adaptive immune responses, and highlight how targeting of these elements by some pathogens can influence the host immune response.}, author = {Mueller, Scott N. and Germain, Ronald N.}, citeulike-article-id = {5637873}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nri2588}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nri2588}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19644499}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19644499}, day = {31}, doi = {10.1038/nri2588}, issn = {1474-1741}, journal = {Nat Rev Immunol}, keywords = {8011, aai}, month = {September}, number = {9}, pages = {618--629}, posted-at = {2009-08-25 13:55:33}, priority = {2}, publisher = {Nature Publishing Group}, title = {Stromal cell contributions to the homeostasis and functionality of the immune system}, url = {http://dx.doi.org/10.1038/nri2588}, volume = {9}, year = {2009} }

TY - JOUR ID - citeulike:5637873 L3 - citeulike-article-id:5637873 N2 - A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the effective development of adaptive immune responses take place. What has only recently been recognized is the role that non-haematopoietic stromal elements have in many aspects of immune cell migration, activation and survival. In this Review, we summarize our current understanding of lymphoid compartment stromal cells, examine their possible heterogeneity, discuss how these cells contribute to immune homeostasis and the efficient initiation of adaptive immune responses, and highlight how targeting of these elements by some pathogens can influence the host immune response. IS - 9 JF - Nat Rev Immunol SN - 1474-1741 EP - 629 TI - Stromal cell contributions to the homeostasis and functionality of the immune system PB - Nature Publishing Group VL - 9 SP - 618 KW - 8011 KW - aai AU - Mueller, Scott AU - Germain, Ronald PY - 2009/09/31/ UR - http://dx.doi.org/10.1038/nri2588 ER -