Rho family GTPases and their regulators in lymphocytes. Export

@article{citeulike:5637875, abstract = {Rho family GTPases, and the proteins that regulate them, have important roles in many cellular processes, including cell division, survival, migration and adhesion. Although most of our understanding of these proteins has come from studies using cell lines, more recent gene targeting studies in mice are providing insights into the in vivo function of these proteins. Here we review recent progress revealing crucial roles for these proteins in lymphocyte development, activation, differentiation and migration. The emerging picture shows that Rho family GTPases transduce signals from receptors for antigens, chemokines and cytokines, as well as adhesion molecules and pattern recognition receptors, and that they function as focal points for crosstalk between different signalling pathways.}, author = {Tybulewicz, Victor L. and Henderson, Robert B.}, citeulike-article-id = {5637875}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nri2606}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19696767}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19696767}, day = {21}, doi = {10.1038/nri2606}, issn = {1474-1741}, journal = {Nature reviews. Immunology}, keywords = {rac, rap1, review}, month = {August}, posted-at = {2009-08-25 13:56:18}, priority = {2}, title = {Rho family GTPases and their regulators in lymphocytes.}, url = {http://dx.doi.org/10.1038/nri2606}, year = {2009} }

TY - JOUR ID - citeulike:5637875 L3 - citeulike-article-id:5637875 N2 - Rho family GTPases, and the proteins that regulate them, have important roles in many cellular processes, including cell division, survival, migration and adhesion. Although most of our understanding of these proteins has come from studies using cell lines, more recent gene targeting studies in mice are providing insights into the in vivo function of these proteins. Here we review recent progress revealing crucial roles for these proteins in lymphocyte development, activation, differentiation and migration. The emerging picture shows that Rho family GTPases transduce signals from receptors for antigens, chemokines and cytokines, as well as adhesion molecules and pattern recognition receptors, and that they function as focal points for crosstalk between different signalling pathways. JF - Nature reviews. Immunology SN - 1474-1741 TI - Rho family GTPases and their regulators in lymphocytes. KW - rac KW - rap1 KW - review AU - Tybulewicz, Victor AU - Henderson, Robert PY - 2009/08/21/ UR - http://dx.doi.org/10.1038/nri2606 ER -