Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Export

@article{citeulike:5977042, abstract = {Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the secretory domain. Both paths utilized the same intracellular molecular events, which have different spatial and temporal arrangements and are regulated by the kinetics of Ca(2+)-mediated signaling. Rapid signaling caused swift granule concentration near the microtubule-organizing center (MTOC) and subsequent delivery by the polarized MTOC directly to the secretory domain-the shortest path. Indolent signaling led to late recruitment of granules that moved along microtubules to the periphery of the synapse and then moved tangentially to fuse at the outer edge of the secretory domain-a longer path. The short pathway is associated with faster granule release and more efficient killing than the long pathway. Thus, the kinetics of early signaling regulates the quality of the T cell cytolytic response.}, author = {Beal, Allison M. and Anikeeva, Nadia and Varma, Rajat and Cameron, Thomas O. and Vasiliver-Shamis, Gaia and Norris, Philip J. and Dustin, Michael L. and Sykulev, Yuri}, citeulike-article-id = {5977042}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2009.09.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1074761309004166}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19833088}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19833088}, day = {16}, doi = {10.1016/j.immuni.2009.09.004}, issn = {1097-4180}, journal = {Immunity}, keywords = {cd8, synapse}, month = {October}, number = {4}, pages = {632--642}, posted-at = {2009-11-02 15:34:28}, priority = {2}, title = {Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.}, url = {http://dx.doi.org/10.1016/j.immuni.2009.09.004}, volume = {31}, year = {2009} }

TY - JOUR ID - citeulike:5977042 L3 - citeulike-article-id:5977042 N2 - Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the secretory domain. Both paths utilized the same intracellular molecular events, which have different spatial and temporal arrangements and are regulated by the kinetics of Ca(2+)-mediated signaling. Rapid signaling caused swift granule concentration near the microtubule-organizing center (MTOC) and subsequent delivery by the polarized MTOC directly to the secretory domain-the shortest path. Indolent signaling led to late recruitment of granules that moved along microtubules to the periphery of the synapse and then moved tangentially to fuse at the outer edge of the secretory domain-a longer path. The short pathway is associated with faster granule release and more efficient killing than the long pathway. Thus, the kinetics of early signaling regulates the quality of the T cell cytolytic response. IS - 4 JF - Immunity SN - 1097-4180 EP - 642 TI - Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. VL - 31 SP - 632 KW - cd8 KW - synapse AU - Beal, Allison AU - Anikeeva, Nadia AU - Varma, Rajat AU - Cameron, Thomas AU - Vasiliver-Shamis, Gaia AU - Norris, Philip AU - Dustin, Michael AU - Sykulev, Yuri PY - 2009/10/16/ UR - http://dx.doi.org/10.1016/j.immuni.2009.09.004 ER -