Essential role of LAT in T cell development. Export

@article{citeulike:6029274, abstract = {The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules. The central role of this molecule in TCR-mediated signaling has been demonstrated by experiments in a LAT-deficient cell line. To probe the role of LAT in T cell development, the LAT gene was disrupted by targeting. LAT-deficient mice appeared healthy. Flow cytometric analysis revealed normal B cell populations but the absence of any mature peripheral T cells. Intrathymic development was blocked within the CD4- CD8- stage. No gross abnormality of NK or platelet function was observed. LAT is thus critical to both T cell activation and development.}, author = {Zhang, W. and Sommers, C. L. and Burshtyn, D. N. and Stebbins, C. C. and DeJarnette, J. B. and Trible, R. P. and Grinberg, A. and Tsay, H. C. and Jacobs, H. M. and Kessler, C. M. and Long, E. O. and Love, P. E. and Samelson, L. E.}, citeulike-article-id = {6029274}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10204488}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10204488}, issn = {1074-7613}, journal = {Immunity}, keywords = {knockout, lat}, month = {March}, number = {3}, pages = {323--332}, posted-at = {2009-10-28 22:12:20}, priority = {2}, title = {Essential role of LAT in T cell development.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10204488}, volume = {10}, year = {1999} }

TY - JOUR ID - citeulike:6029274 L3 - citeulike-article-id:6029274 N2 - The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules. The central role of this molecule in TCR-mediated signaling has been demonstrated by experiments in a LAT-deficient cell line. To probe the role of LAT in T cell development, the LAT gene was disrupted by targeting. LAT-deficient mice appeared healthy. Flow cytometric analysis revealed normal B cell populations but the absence of any mature peripheral T cells. Intrathymic development was blocked within the CD4- CD8- stage. No gross abnormality of NK or platelet function was observed. LAT is thus critical to both T cell activation and development. IS - 3 JF - Immunity SN - 1074-7613 EP - 332 TI - Essential role of LAT in T cell development. VL - 10 SP - 323 KW - knockout KW - lat AU - Zhang, W AU - Sommers, CL AU - Burshtyn, DN AU - Stebbins, CC AU - DeJarnette, JB AU - Trible, RP AU - Grinberg, A AU - Tsay, HC AU - Jacobs, HM AU - Kessler, CM AU - Long, EO AU - Love, PE AU - Samelson, LE PY - 1999/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/10204488 ER -