TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells Export

@article{citeulike:6044770, abstract = {Memory T cells are more responsive to Ag than naive cells. To determine whether memory T cells also have more efficient TCR signaling, we compared naive, effector, and memory CD8 T cells of the same antigenic specificity. Surprisingly, initial CD3 signaling events are indistinguishable. However, memory T cells have more extensive lipid rafts with higher phosphoprotein content before TCR engagement. Upon activation in vivo, they more efficiently induce phosphorylation of-LAT (linker for activation of T cells), ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase), and p38. Thus, memory CD8 T cells do not increase their TCR sensitivity, but are better poised to augment downstream signals. We propose that this regulatory mechanism might increase signal transduction in memory T cells, while limiting TCR cross-reactivity and autoimmunity.}, author = {Kersh, Ellen N. and Kaech, Susan M. and Onami, Thandi M. and Moran, Miriana and Wherry, E. John and Miceli, M. Carrie and Ahmed, Rafi}, citeulike-article-id = {6044770}, citeulike-linkout-0 = {http://www.jimmunol.org/content/170/11/5455.abstract}, citeulike-linkout-1 = {http://www.jimmunol.org/content/170/11/5455.full.pdf}, day = {1}, journal = {J Immunol}, keywords = {facs, tcr}, month = {June}, number = {11}, pages = {5455--5463}, posted-at = {2009-10-30 20:51:50}, priority = {2}, title = {TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells}, url = {http://www.jimmunol.org/content/170/11/5455.abstract}, volume = {170}, year = {2002} }

TY - JOUR ID - citeulike:6044770 L3 - citeulike-article-id:6044770 N2 - Memory T cells are more responsive to Ag than naive cells. To determine whether memory T cells also have more efficient TCR signaling, we compared naive, effector, and memory CD8 T cells of the same antigenic specificity. Surprisingly, initial CD3 signaling events are indistinguishable. However, memory T cells have more extensive lipid rafts with higher phosphoprotein content before TCR engagement. Upon activation in vivo, they more efficiently induce phosphorylation of-LAT (linker for activation of T cells), ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase), and p38. Thus, memory CD8 T cells do not increase their TCR sensitivity, but are better poised to augment downstream signals. We propose that this regulatory mechanism might increase signal transduction in memory T cells, while limiting TCR cross-reactivity and autoimmunity. IS - 11 JF - J Immunol EP - 5463 TI - TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells VL - 170 SP - 5455 KW - facs KW - tcr AU - Kersh, Ellen AU - Kaech, Susan AU - Onami, Thandi AU - Moran, Miriana AU - Wherry, John AU - Miceli, Carrie AU - Ahmed, Rafi PY - 2002/06/01/ UR - http://www.jimmunol.org/content/170/11/5455.abstract ER -