The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells Export

@article{citeulike:763307, abstract = {Apoptosis of activated T cells is critical for the termination of immune responses. Here we show that adjuvant-stimulated dendritic cells secrete cytokines that prime activated T cells for survival and analyze the roles of the NF-{kappa}B regulator Bcl-3 and the proapoptotic Bcl-2 family members Bim and Puma. Bcl-3 overexpression increased survival, and activated bcl-3-/- T cells died abnormally rapidly. Cytokines from adjuvant-stimulated dendritic cells induced Bcl-3, but survival through cytokine priming was Bcl-3-independent. Apoptosis inhibition by Bcl-3 involved blockade of Bim activation, because Bim was overactivated in Bcl-3-deficient cells, and Bcl-3 failed to increase survival of bim-/- T cells. However, adjuvants increased survival also in Bim-deficient T cells. This Bim-independent death pathway is at least in part regulated by Puma, as shown by analysis of puma-/- and noxa-/- T cells. IL-1, IL-7, and IL-15 primed T cells for survival even in the absence of Bim or Puma. Our data define interrelations and a Bim-independent pathway to activated T cell death. 10.1073/pnas.0603625103}, author = {Bauer, Anette and Villunger, Andreas and Labi, Verena and Fischer, Silke F. and Strasser, Andreas and Wagner, Hermann and Schmid, Roland M. and Hacker, Georg}, citeulike-article-id = {763307}, citeulike-linkout-0 = {http://www.pnas.org/cgi/content/abstract/103/29/10979}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16832056}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16832056}, day = {18}, journal = {PNAS}, keywords = {apoptosis, bcl-3, nfkb}, month = {July}, number = {29}, pages = {10979--10984}, posted-at = {2006-07-18 18:33:22}, priority = {3}, title = {The NF-{kappa}B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells}, url = {http://www.pnas.org/cgi/content/abstract/103/29/10979}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:763307 L3 - citeulike-article-id:763307 N2 - Apoptosis of activated T cells is critical for the termination of immune responses. Here we show that adjuvant-stimulated dendritic cells secrete cytokines that prime activated T cells for survival and analyze the roles of the NF-{kappa}B regulator Bcl-3 and the proapoptotic Bcl-2 family members Bim and Puma. Bcl-3 overexpression increased survival, and activated bcl-3-/- T cells died abnormally rapidly. Cytokines from adjuvant-stimulated dendritic cells induced Bcl-3, but survival through cytokine priming was Bcl-3-independent. Apoptosis inhibition by Bcl-3 involved blockade of Bim activation, because Bim was overactivated in Bcl-3-deficient cells, and Bcl-3 failed to increase survival of bim-/- T cells. However, adjuvants increased survival also in Bim-deficient T cells. This Bim-independent death pathway is at least in part regulated by Puma, as shown by analysis of puma-/- and noxa-/- T cells. IL-1, IL-7, and IL-15 primed T cells for survival even in the absence of Bim or Puma. Our data define interrelations and a Bim-independent pathway to activated T cell death. 10.1073/pnas.0603625103 IS - 29 JF - PNAS EP - 10984 TI - The NF-{kappa}B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells VL - 103 SP - 10979 KW - apoptosis KW - bcl-3 KW - nfkb AU - Bauer, Anette AU - Villunger, Andreas AU - Labi, Verena AU - Fischer, Silke AU - Strasser, Andreas AU - Wagner, Hermann AU - Schmid, Roland AU - Hacker, Georg PY - 2006/07/18/ UR - http://www.pnas.org/cgi/content/abstract/103/29/10979 ER -