Combined analog and action potential coding in hippocampal mossy fibers. Export

@article{citeulike:1719906, abstract = {In the mammalian cortex, it is generally assumed that the output information of neurons is encoded in the number and the timing of action potentials. Here, we show, by using direct patchclamp recordings from presynaptic hippocampal mossy fiber boutons, that axons transmit analog signals in addition to action potentials. Excitatory presynaptic potentials result from subthreshold dendritic synaptic inputs, which propagate several hundreds of micrometers along the axon and modulate action potential-evoked transmitter release at the mossy fiber-CA3 synapse. This combined analog and action potential coding represents an additional mechanism for information transmission in a major hippocampal pathway.}, author = {Alle, H. and Geiger, J. R.}, citeulike-article-id = {1719906}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1119055}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/311/5765/1290}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16513983}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16513983}, day = {3}, doi = {10.1126/science.1119055}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {analog\_signaling, graded\_potentials}, month = {March}, number = {5765}, pages = {1290--1293}, posted-at = {2008-09-30 15:25:36}, priority = {2}, title = {Combined analog and action potential coding in hippocampal mossy fibers.}, url = {http://dx.doi.org/10.1126/science.1119055}, volume = {311}, year = {2006} }

TY - JOUR ID - citeulike:1719906 L3 - citeulike-article-id:1719906 N2 - In the mammalian cortex, it is generally assumed that the output information of neurons is encoded in the number and the timing of action potentials. Here, we show, by using direct patchclamp recordings from presynaptic hippocampal mossy fiber boutons, that axons transmit analog signals in addition to action potentials. Excitatory presynaptic potentials result from subthreshold dendritic synaptic inputs, which propagate several hundreds of micrometers along the axon and modulate action potential-evoked transmitter release at the mossy fiber-CA3 synapse. This combined analog and action potential coding represents an additional mechanism for information transmission in a major hippocampal pathway. IS - 5765 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1293 TI - Combined analog and action potential coding in hippocampal mossy fibers. VL - 311 SP - 1290 KW - analog_signaling KW - graded_potentials AU - Alle, H AU - Geiger, JR PY - 2006/03/03/ UR - http://dx.doi.org/10.1126/science.1119055 ER -