Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals Export

@article{citeulike:3823340, abstract = {The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. Accordingly, the fatty acids analyses of liver mitochondria from eight mammals, ranging in maximum life span from 3.5 to 46 years, show that the total number of double bonds and the peroxidizability index are negatively correlated with maximum life span (r = -0. 88, P < 0.003; r = -0.87, P < 0.004, respectively). This is not due to a low content of unsaturated fatty acids in longevous animals, but mainly to a redistribution between kinds of the polyunsaturated n-3 fatty acids series, shifting from the highly unsaturated docosahexaenoic acid (r = -0.89, P < 0.003) to the less unsaturated linolenic acid (r = 0.97, P < 0.0001). This redistribution pattern strongly suggests the presence of a constitutively low {Delta}6-desaturase activity in longevous animals (r = -0.96, P < 0.0001). Thus, it may be proposed that, during evolution, a low degree of fatty acid unsaturation in liver mitochondria may have been selected in longevous mammals in order to protect the tissues against oxidative damage, while maintaining an appropriate environment for membrane function.--Pamplona, R., M. Portero-Otin, D. Riba, C. Ruiz, J. Prat, M. J. Bellmunt, and G. Barja. Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J. Lipid Res. 1998. 39: 1989-1994.}, author = {Pamplona, Reinald and Portero-Otin, Manuel and Riba, David and Ruiz, Cristina and Prat, Joan and Bellmunt, Maria J. and Barja, Gustavo}, citeulike-article-id = {3823340}, citeulike-linkout-0 = {http://www.jlr.org/cgi/content/abstract/39/10/1989}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/9788245}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=9788245}, day = {1}, journal = {J. Lipid Res.}, keywords = {ageing, oxidative\_stress, unsaturated\_fats}, month = {October}, number = {10}, pages = {1989--1994}, posted-at = {2008-12-24 22:32:28}, priority = {2}, title = {Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals}, url = {http://www.jlr.org/cgi/content/abstract/39/10/1989}, volume = {39}, year = {1998} }

TY - JOUR ID - citeulike:3823340 L3 - citeulike-article-id:3823340 N2 - The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. Accordingly, the fatty acids analyses of liver mitochondria from eight mammals, ranging in maximum life span from 3.5 to 46 years, show that the total number of double bonds and the peroxidizability index are negatively correlated with maximum life span (r = -0. 88, P < 0.003; r = -0.87, P < 0.004, respectively). This is not due to a low content of unsaturated fatty acids in longevous animals, but mainly to a redistribution between kinds of the polyunsaturated n-3 fatty acids series, shifting from the highly unsaturated docosahexaenoic acid (r = -0.89, P < 0.003) to the less unsaturated linolenic acid (r = 0.97, P < 0.0001). This redistribution pattern strongly suggests the presence of a constitutively low {Delta}6-desaturase activity in longevous animals (r = -0.96, P < 0.0001). Thus, it may be proposed that, during evolution, a low degree of fatty acid unsaturation in liver mitochondria may have been selected in longevous mammals in order to protect the tissues against oxidative damage, while maintaining an appropriate environment for membrane function.--Pamplona, R., M. Portero-Otin, D. Riba, C. Ruiz, J. Prat, M. J. Bellmunt, and G. Barja. Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J. Lipid Res. 1998. 39: 1989-1994. IS - 10 JF - J. Lipid Res. EP - 1994 TI - Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals VL - 39 SP - 1989 KW - ageing KW - oxidative_stress KW - unsaturated_fats AU - Pamplona, Reinald AU - Portero-Otin, Manuel AU - Riba, David AU - Ruiz, Cristina AU - Prat, Joan AU - Bellmunt, Maria AU - Barja, Gustavo PY - 1998/10/01/ UR - http://www.jlr.org/cgi/content/abstract/39/10/1989 ER -