Insulin and neurodegenerative disease: shared and specific mechanisms. Export

@article{citeulike:4184055, abstract = {Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.}, author = {Craft, S. and Watson, G. S.}, citeulike-article-id = {4184055}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S1474-4422(04)00681-7}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14980532}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14980532}, doi = {10.1016/S1474-4422(04)00681-7}, issn = {1474-4422}, journal = {Lancet neurology}, keywords = {cardiovascular, cognitive\_ageing, insulin, oxidative\_stress}, month = {March}, number = {3}, pages = {169--178}, posted-at = {2009-03-16 17:20:34}, priority = {2}, title = {Insulin and neurodegenerative disease: shared and specific mechanisms.}, url = {http://dx.doi.org/10.1016/S1474-4422(04)00681-7}, volume = {3}, year = {2004} }

TY - JOUR ID - citeulike:4184055 L3 - citeulike-article-id:4184055 N2 - Insulin has functions in the brain and dysregulation of these functions may contribute to the expression of late-life neurodegenerative disease. We provide a brief summary of research on the influence of insulin on normal brain function. We then review evidence that perturbation of this role may contribute to the symptoms and pathogenesis of various neurodegenerative disorders, such as Alzheimer's disease, vascular dementia, Parkinson's disease, and Huntington's disease. We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms. IS - 3 JF - Lancet neurology SN - 1474-4422 EP - 178 TI - Insulin and neurodegenerative disease: shared and specific mechanisms. VL - 3 SP - 169 KW - cardiovascular KW - cognitive_ageing KW - insulin KW - oxidative_stress AU - Craft, S AU - Watson, GS PY - 2004/03// UR - http://dx.doi.org/10.1016/S1474-4422(04)00681-7 ER -