Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure Export

@article{citeulike:4569159, abstract = {<title>Author Summary</title> <p>Cytomegalovirus (CMV) infection is associated with cardiovascular diseases. The exact mechanisms, however, remain to be defined. Using both mouse model and cell culture analyses, we find that CMV infection alone causes an increase in blood pressure. Additionally, CMV infection augments the increased blood pressure induced by a high cholesterol diet. CMV infection alone, however, does not cause atherosclerosis in aortas. CMV infection along with a high cholesterol diet, however, causes the classic atherosclerotic plaque formation in the main artery connected to the heart. Further studies show that CMV infection induces renin and angiotensin II (Ang II) expression in blood and in vessel cells, in a persistent infection manner. An increased expression of renin and Ang II has been known to cause an increase in blood pressure or hypertension in humans. Expression of viral genes and viral persistent infection of blood vessel endothelial cells resulting in an increased expression of inflammatory cytokines, including renin and Ang II, may underpin the molecular mechanism by which CMV infection induces an increase in blood pressure.</p>}, author = {Cheng, Jilin and Ke, Qingen and Jin, Zhuang and Wang, Haibin and Kocher, Olivier and Morgan, James P. and Zhang, Jielin and Crumpacker, Clyde S.}, citeulike-article-id = {4569159}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.ppat.1000427}, day = {15}, doi = {10.1371/journal.ppat.1000427}, journal = {PLoS Pathog}, keywords = {cardiovascular, health, infection}, month = {May}, number = {5}, pages = {e1000427+}, posted-at = {2009-05-21 13:19:44}, priority = {2}, publisher = {Public Library of Science}, title = {Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure}, url = {http://dx.doi.org/10.1371/journal.ppat.1000427}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:4569159 L3 - citeulike-article-id:4569159 N2 - <title>Author Summary</title> <p>Cytomegalovirus (CMV) infection is associated with cardiovascular diseases. The exact mechanisms, however, remain to be defined. Using both mouse model and cell culture analyses, we find that CMV infection alone causes an increase in blood pressure. Additionally, CMV infection augments the increased blood pressure induced by a high cholesterol diet. CMV infection alone, however, does not cause atherosclerosis in aortas. CMV infection along with a high cholesterol diet, however, causes the classic atherosclerotic plaque formation in the main artery connected to the heart. Further studies show that CMV infection induces renin and angiotensin II (Ang II) expression in blood and in vessel cells, in a persistent infection manner. An increased expression of renin and Ang II has been known to cause an increase in blood pressure or hypertension in humans. Expression of viral genes and viral persistent infection of blood vessel endothelial cells resulting in an increased expression of inflammatory cytokines, including renin and Ang II, may underpin the molecular mechanism by which CMV infection induces an increase in blood pressure.</p> IS - 5 JF - PLoS Pathog TI - Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure PB - Public Library of Science VL - 5 SP - e1000427 KW - cardiovascular KW - health KW - infection AU - Cheng, Jilin AU - Ke, Qingen AU - Jin, Zhuang AU - Wang, Haibin AU - Kocher, Olivier AU - Morgan, James AU - Zhang, Jielin AU - Crumpacker, Clyde PY - 2009/05/15/ UR - http://dx.doi.org/10.1371/journal.ppat.1000427 ER -