A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence. Export

@article{citeulike:1066587, abstract = {OBJECTIVE: Problems related to illegal amphetamine use have become a major public health issue in many developed countries. To date, evidence on the effectiveness of psychosocial treatments has remained modest, and no pharmacotherapy has proven effective for amphetamine dependence. METHOD: Individuals meeting DSM-IV criteria for intravenous amphetamine dependence (N=53) were randomly assigned to receive aripiprazole (15 mg/day), slow-release methylphenidate (54 mg/day), or placebo for 20 weeks. The study was terminated prematurely due to unexpected results of interim analysis. An intention-to-treat analysis was used. The primary outcome measure was the proportion of amphetamine-positive urine samples. RESULTS: Patients allocated to aripiprazole had significantly more amphetamine-positive urine samples than patients in the placebo group (odds ratio=3.77, 95\% CI=1.55-9.18), whereas patients who received methylphenidate had significantly fewer amphetamine-positive urine samples than patients who had received placebo (odds ratio=0.46, 95\% CI=0.26-0.81). CONCLUSIONS: Methylphenidate is an effective treatment for reducing intravenous drug use in patients with severe amphetamine dependence.}, address = {Department of Forensic Psychiatry, University of Kuopio, and the Department of Psychiatry, Helsinki University Hospital, Finland. jari.tiihonen@niuva.fi}, author = {Tiihonen, J. and Kuoppasalmi, K. and F\"{o}hr, J. and Tuomola, P. and Kuikanm\"{a}ki, O. and Vorma, H. and Sokero, P. and Haukka, J. and Meririnne, E.}, citeulike-article-id = {1066587}, citeulike-linkout-0 = {http://dx.doi.org/10.1176/appi.ajp.164.1.160}, citeulike-linkout-1 = {http://ajp.psychiatryonline.org/cgi/content/abstract/164/1/160}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17202560}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17202560}, doi = {10.1176/appi.ajp.164.1.160}, issn = {0002-953X}, journal = {Am J Psychiatry}, keywords = {amphetamine, aripiprazole, methylphenidate, treatment}, month = {January}, number = {1}, pages = {160--162}, posted-at = {2007-11-16 20:40:59}, priority = {4}, title = {A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence.}, url = {http://dx.doi.org/10.1176/appi.ajp.164.1.160}, volume = {164}, year = {2007} }

TY - JOUR ID - citeulike:1066587 L3 - citeulike-article-id:1066587 N2 - OBJECTIVE: Problems related to illegal amphetamine use have become a major public health issue in many developed countries. To date, evidence on the effectiveness of psychosocial treatments has remained modest, and no pharmacotherapy has proven effective for amphetamine dependence. METHOD: Individuals meeting DSM-IV criteria for intravenous amphetamine dependence (N=53) were randomly assigned to receive aripiprazole (15 mg/day), slow-release methylphenidate (54 mg/day), or placebo for 20 weeks. The study was terminated prematurely due to unexpected results of interim analysis. An intention-to-treat analysis was used. The primary outcome measure was the proportion of amphetamine-positive urine samples. RESULTS: Patients allocated to aripiprazole had significantly more amphetamine-positive urine samples than patients in the placebo group (odds ratio=3.77, 95% CI=1.55-9.18), whereas patients who received methylphenidate had significantly fewer amphetamine-positive urine samples than patients who had received placebo (odds ratio=0.46, 95% CI=0.26-0.81). CONCLUSIONS: Methylphenidate is an effective treatment for reducing intravenous drug use in patients with severe amphetamine dependence. IS - 1 JF - Am J Psychiatry SN - 0002-953X AD - Department of Forensic Psychiatry, University of Kuopio, and the Department of Psychiatry, Helsinki University Hospital, Finland. jari.tiihonen@niuva.fi EP - 162 TI - A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence. VL - 164 SP - 160 KW - amphetamine KW - aripiprazole KW - methylphenidate KW - treatment AU - Tiihonen, J AU - Kuoppasalmi, K AU - Föhr, J AU - Tuomola, P AU - Kuikanmäki, O AU - Vorma, H AU - Sokero, P AU - Haukka, J AU - Meririnne, E PY - 2007/01// UR - http://dx.doi.org/10.1176/appi.ajp.164.1.160 ER -