Impact of Prenatal Cocaine Exposure on Child Behavior Problems Through School Age Export

@article{citeulike:1465733, abstract = {OBJECTIVE. We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS. The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS. High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS. Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes. 10.1542/peds.2006-1404}, author = {Bada, Henrietta S. and Das, Abhik and Bauer, Charles R. and Shankaran, Seetha and Lester, Barry and Lagasse, Linda and Hammond, Jane and Wright, Linda L. and Higgins, Rosemary}, citeulike-article-id = {1465733}, citeulike-linkout-0 = {http://dx.doi.org/10.1542/peds.2006-1404}, citeulike-linkout-1 = {http://pediatrics.aappublications.org/cgi/content/abstract/119/2/e348}, citeulike-linkout-2 = {http://pediatrics.aappublications.org/cgi/reprint/119/2/e348}, comment = {URL free}, day = {1}, doi = {10.1542/peds.2006-1404}, journal = {Pediatrics}, keywords = {child-behavior, cocaine, prenatal, school}, month = {February}, number = {2}, pages = {e348--359}, posted-at = {2007-07-18 22:27:10}, priority = {2}, title = {Impact of Prenatal Cocaine Exposure on Child Behavior Problems Through School Age}, url = {http://dx.doi.org/10.1542/peds.2006-1404}, volume = {119}, year = {2007} }

TY - JOUR ID - citeulike:1465733 L3 - citeulike-article-id:1465733 N2 - OBJECTIVE. We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS. The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS. High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS. Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes. 10.1542/peds.2006-1404 IS - 2 JF - Pediatrics EP - 359 TI - Impact of Prenatal Cocaine Exposure on Child Behavior Problems Through School Age VL - 119 SP - e348 KW - child-behavior KW - cocaine KW - prenatal KW - school N1 - URL free AU - Bada, Henrietta AU - Das, Abhik AU - Bauer, Charles AU - Shankaran, Seetha AU - Lester, Barry AU - Lagasse, Linda AU - Hammond, Jane AU - Wright, Linda AU - Higgins, Rosemary PY - 2007/02/01/ UR - http://dx.doi.org/10.1542/peds.2006-1404 ER -