Impaired inhibitory control in recreational cocaine users. Export

@article{citeulike:1900469, abstract = {Chronic use of cocaine is associated with impairment in response inhibition but it is an open question whether and to which degree findings from chronic users generalize to the upcoming type of recreational users. This study compared the ability to inhibit and execute behavioral responses in adult recreational users and in a cocaine-free-matched sample controlled for age, race, gender distribution, level of intelligence, and alcohol consumption. Response inhibition and response execution were measured by a stop-signal paradigm. Results show that users and non users are comparable in terms of response execution but users need significantly more time to inhibit responses to stop-signals than non users. Interestingly, the magnitude of the inhibitory deficit was positively correlated with the individuals lifetime cocaine exposure suggesting that the magnitude of the impairment is proportional to the degree of cocaine consumed.}, address = {Institute for Psychological Research and Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.}, author = {Colzato, L. S. and van den Wildenberg, W. P. and Hommel, B.}, citeulike-article-id = {1900469}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0001143}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17989775}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17989775}, doi = {10.1371/journal.pone.0001143}, issn = {1932-6203}, journal = {PLoS ONE}, keywords = {cocaine, executive-functions, inhibition-response, stop-signal-paradigm}, number = {11}, posted-at = {2008-01-25 19:38:32}, priority = {4}, title = {Impaired inhibitory control in recreational cocaine users.}, url = {http://dx.doi.org/10.1371/journal.pone.0001143}, volume = {2}, year = {2007} }

TY - JOUR ID - citeulike:1900469 L3 - citeulike-article-id:1900469 N2 - Chronic use of cocaine is associated with impairment in response inhibition but it is an open question whether and to which degree findings from chronic users generalize to the upcoming type of recreational users. This study compared the ability to inhibit and execute behavioral responses in adult recreational users and in a cocaine-free-matched sample controlled for age, race, gender distribution, level of intelligence, and alcohol consumption. Response inhibition and response execution were measured by a stop-signal paradigm. Results show that users and non users are comparable in terms of response execution but users need significantly more time to inhibit responses to stop-signals than non users. Interestingly, the magnitude of the inhibitory deficit was positively correlated with the individuals lifetime cocaine exposure suggesting that the magnitude of the impairment is proportional to the degree of cocaine consumed. IS - 11 JF - PLoS ONE SN - 1932-6203 AD - Institute for Psychological Research and Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands. TI - Impaired inhibitory control in recreational cocaine users. VL - 2 KW - cocaine KW - executive-functions KW - inhibition-response KW - stop-signal-paradigm AU - Colzato, LS AU - van den Wildenberg, WP AU - Hommel, B PY - 2007/// UR - http://dx.doi.org/10.1371/journal.pone.0001143 ER -