Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone--a multiple-dose study. Export

@article{citeulike:4302219, abstract = {BACKGROUND: Simultaneous abuse of cocaine and alcohol is widespread and increasingly detected in patients seeking emergent care. This double-blind, randomized, within-subjects study used a paradigm more closely approximating practices of drug abusers to better understand the pathogenesis of cocaine-alcohol abuse. METHODS: Subjects meeting DSM-IV criteria for cocaine dependence and alcohol abuse participated in three drug administration sessions: four doses of intranasal cocaine (1 mg/kg every 30 min) with oral alcohol (1 g/kg) administered following the initial cocaine dose and a second dose (120 mg/kg) at 60 min calculated to maintain plasma alcohol concentration at approximately 100 mg/dL during cocaine administration; four doses of cocaine/placebo alcohol; four doses of cocaine placebo/alcohol. Pharmacokinetic, physiological, and behavioral effects were followed over 8 hours. RESULTS: Cocaine-alcohol produced greater euphoria and increased perception of well-being relative to cocaine. Heart rate significantly increased following cocaine-alcohol administration relative to either drug alone. Cocaine concentrations were greater following cocaine-alcohol administration. Cocaethylene had a longer halflife with increasing concentrations relative to cocaine at later time points. CONCLUSIONS: Enhanced psychological effects during cocaine-alcohol abuse may encourage ingestion of larger amounts of these substances over time placing users at heightened risk for greater toxicity than with either drug alone.}, author = {Mccance-Katz, E. F. and Kosten, T. R. and Jatlow, P.}, citeulike-article-id = {4302219}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9715356}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9715356}, day = {15}, issn = {0006-3223}, journal = {Biological psychiatry}, keywords = {alcohol, cocaethylene, cocaine, human, physiology, toxicity}, month = {August}, number = {4}, pages = {250--259}, posted-at = {2009-04-11 23:19:22}, priority = {2}, title = {Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone--a multiple-dose study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9715356}, volume = {44}, year = {1998} }

TY - JOUR ID - citeulike:4302219 L3 - citeulike-article-id:4302219 N2 - BACKGROUND: Simultaneous abuse of cocaine and alcohol is widespread and increasingly detected in patients seeking emergent care. This double-blind, randomized, within-subjects study used a paradigm more closely approximating practices of drug abusers to better understand the pathogenesis of cocaine-alcohol abuse. METHODS: Subjects meeting DSM-IV criteria for cocaine dependence and alcohol abuse participated in three drug administration sessions: four doses of intranasal cocaine (1 mg/kg every 30 min) with oral alcohol (1 g/kg) administered following the initial cocaine dose and a second dose (120 mg/kg) at 60 min calculated to maintain plasma alcohol concentration at approximately 100 mg/dL during cocaine administration; four doses of cocaine/placebo alcohol; four doses of cocaine placebo/alcohol. Pharmacokinetic, physiological, and behavioral effects were followed over 8 hours. RESULTS: Cocaine-alcohol produced greater euphoria and increased perception of well-being relative to cocaine. Heart rate significantly increased following cocaine-alcohol administration relative to either drug alone. Cocaine concentrations were greater following cocaine-alcohol administration. Cocaethylene had a longer halflife with increasing concentrations relative to cocaine at later time points. CONCLUSIONS: Enhanced psychological effects during cocaine-alcohol abuse may encourage ingestion of larger amounts of these substances over time placing users at heightened risk for greater toxicity than with either drug alone. IS - 4 JF - Biological psychiatry SN - 0006-3223 EP - 259 TI - Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone--a multiple-dose study. VL - 44 SP - 250 KW - alcohol KW - cocaethylene KW - cocaine KW - human KW - physiology KW - toxicity AU - Mccance-Katz, EF AU - Kosten, TR AU - Jatlow, P PY - 1998/08/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9715356 ER -