Functional metagenomic profiling of nine biomes Export

@article{citeulike:2528048, abstract = {Microbial activities shape the biogeochemistry of the planet1, 2 and macroorganism health3. Determining the metabolic processes performed by microbes is important both for understanding and for manipulating ecosystems (for example, disruption of key processes that lead to disease, conservation of environmental services, and so on). Describing microbial function is hampered by the inability to culture most microbes and by high levels of genomic plasticity. Metagenomic approaches analyse microbial communities to determine the metabolic processes that are important for growth and survival in any given environment. Here we conduct a metagenomic comparison of almost 15 million sequences from 45 distinct microbiomes and, for the first time, 42 distinct viromes and show that there are strongly discriminatory metabolic profiles across environments. Most of the functional diversity was maintained in all of the communities, but the relative occurrence of metabolisms varied, and the differences between metagenomes predicted the biogeochemical conditions of each environment. The magnitude of the microbial metabolic capabilities encoded by the viromes was extensive, suggesting that they serve as a repository for storing and sharing genes among their microbial hosts and influence global evolutionary and metabolic processes.}, author = {Dinsdale, Elizabeth A. and Edwards, Robert A. and Hall, Dana and Angly, Florent and Breitbart, Mya and Brulc, Jennifer M. and Furlan, Mike and Desnues, Christelle and Haynes, Matthew and Li, Linlin and McDaniel, Lauren and Moran, Mary A. and Nelson, Karen E. and Nilsson, Christina and Olson, Robert and Paul, John and Brito, Beltran R. and Ruan, Yijun and Swan, Brandon K. and Stevens, Rick and Valentine, David L. and Thurber, Rebecca V. and Wegley, Linda and White, Bryan A. and Rohwer, Forest}, citeulike-article-id = {2528048}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature06810}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature06810}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18337718}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18337718}, day = {12}, doi = {10.1038/nature06810}, issn = {0028-0836}, journal = {Nature}, keywords = {bioinformatics, gut\_flora, metagenomics, microbiome, mosquito, sequencing, virome}, month = {March}, number = {7187}, pages = {629--632}, posted-at = {2009-06-04 21:30:00}, priority = {0}, publisher = {Nature Publishing Group}, title = {Functional metagenomic profiling of nine biomes}, url = {http://dx.doi.org/10.1038/nature06810}, volume = {452}, year = {2008} }

TY - JOUR ID - citeulike:2528048 L3 - citeulike-article-id:2528048 N2 - Microbial activities shape the biogeochemistry of the planet1, 2 and macroorganism health3. Determining the metabolic processes performed by microbes is important both for understanding and for manipulating ecosystems (for example, disruption of key processes that lead to disease, conservation of environmental services, and so on). Describing microbial function is hampered by the inability to culture most microbes and by high levels of genomic plasticity. Metagenomic approaches analyse microbial communities to determine the metabolic processes that are important for growth and survival in any given environment. Here we conduct a metagenomic comparison of almost 15 million sequences from 45 distinct microbiomes and, for the first time, 42 distinct viromes and show that there are strongly discriminatory metabolic profiles across environments. Most of the functional diversity was maintained in all of the communities, but the relative occurrence of metabolisms varied, and the differences between metagenomes predicted the biogeochemical conditions of each environment. The magnitude of the microbial metabolic capabilities encoded by the viromes was extensive, suggesting that they serve as a repository for storing and sharing genes among their microbial hosts and influence global evolutionary and metabolic processes. IS - 7187 JF - Nature SN - 0028-0836 EP - 632 TI - Functional metagenomic profiling of nine biomes PB - Nature Publishing Group VL - 452 SP - 629 KW - bioinformatics KW - gut_flora KW - metagenomics KW - microbiome KW - mosquito KW - sequencing KW - virome AU - Dinsdale, Elizabeth AU - Edwards, Robert AU - Hall, Dana AU - Angly, Florent AU - Breitbart, Mya AU - Brulc, Jennifer AU - Furlan, Mike AU - Desnues, Christelle AU - Haynes, Matthew AU - Li, Linlin AU - McDaniel, Lauren AU - Moran, Mary AU - Nelson, Karen AU - Nilsson, Christina AU - Olson, Robert AU - Paul, John AU - Brito, Beltran AU - Ruan, Yijun AU - Swan, Brandon AU - Stevens, Rick AU - Valentine, David AU - Thurber, Rebecca AU - Wegley, Linda AU - White, Bryan AU - Rohwer, Forest PY - 2008/03/12/ UR - http://dx.doi.org/10.1038/nature06810 ER -