The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Export

@article{citeulike:3683075, abstract = {Mathematical models predict that the future of the multidrug-resistant tuberculosis epidemic will depend on the fitness cost of drug resistance. We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost and that this cost is determined by the specific resistance mutation and strain genetic background. In contrast, we demonstrate that prolonged patient treatment can result in multidrug-resistant strains with no fitness defect and that strains with low- or no-cost resistance mutations are also the most frequent among clinical isolates.}, author = {Gagneux, S. and Long, C. D. and Small, P. M. and Van, T. and Schoolnik, G. K. and Bohannan, B. J.}, citeulike-article-id = {3683075}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1124410}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/312/5782/1944}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16809538}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16809538}, day = {30}, doi = {10.1126/science.1124410}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {antibiotic, bacteria, drug, fitness, resistance, tuberculosis}, month = {June}, number = {5782}, pages = {1944--1946}, posted-at = {2009-01-16 20:48:01}, priority = {2}, title = {The competitive cost of antibiotic resistance in Mycobacterium tuberculosis.}, url = {http://dx.doi.org/10.1126/science.1124410}, volume = {312}, year = {2006} }

TY - JOUR ID - citeulike:3683075 L3 - citeulike-article-id:3683075 N2 - Mathematical models predict that the future of the multidrug-resistant tuberculosis epidemic will depend on the fitness cost of drug resistance. We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost and that this cost is determined by the specific resistance mutation and strain genetic background. In contrast, we demonstrate that prolonged patient treatment can result in multidrug-resistant strains with no fitness defect and that strains with low- or no-cost resistance mutations are also the most frequent among clinical isolates. IS - 5782 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1946 TI - The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. VL - 312 SP - 1944 KW - antibiotic KW - bacteria KW - drug KW - fitness KW - resistance KW - tuberculosis AU - Gagneux, S AU - Long, CD AU - Small, PM AU - Van, T AU - Schoolnik, GK AU - Bohannan, BJ PY - 2006/06/30/ UR - http://dx.doi.org/10.1126/science.1124410 ER -