Membrane Interactions of Mastoparan Analogs Related to Their Differential-Effects on Protein-Kinase-C, Na,K-Atpase and Hl-60 Cells Export

@article{Raynor1992, abstract = {Membrane interactions of tetradecapeptide toxin mastoparan (MP) and analogues (MP-3, MP-X and polistes MP), as indicated by inhibition of various enzymatic and cellular activities, were investigated. MP-3 was found to be the least active in inhibiting protein kinase C (PKC; activated by phosphatidylserine vesicles, synaptosomal membranes or phorbol ester), synaptosomal membrane Na,K-ATPase and proliferation and viability of leukemia HL60 cells. MP-3, however, was as active as others in inhibiting PKC activated by arachidonate monomers and phorbol ester binding. The unique properties of MP-3, the [des-Ile1-Asn2]- analogue of MP, might be related to its low functional amphiphilicity compared to others and useful in further delineating biological activities associated with or regulated by membranes.}, address = {Emory Univ,Sch Med,Dept Pharmacol,Atlanta,Ga 30322Emory Univ,Sch Med,Dept Med,Atlanta,Ga 30322}, author = {Raynor, R. L. and Kim, Y. S. and Bin, Z. and Vogler, W. R. and Kuo, J. F.}, citeulike-article-id = {1868168}, citeulike-linkout-0 = {#}, comment = {Jh396Times Cited:13Cited References Count:24}, journal = {Febs Letters}, keywords = {analogs, and, bibtex-import, mastoparan}, pages = {275--279}, posted-at = {2007-11-05 13:42:19}, priority = {2}, title = {Membrane Interactions of Mastoparan Analogs Related to Their Differential-Effects on Protein-Kinase-C, Na,K-Atpase and Hl-60 Cells}, url = {<Go to ISI>://A1992JH39600008}, volume = {307}, year = {1992} }

TY - JOUR ID - Raynor1992 L3 - citeulike-article-id:1868168 N2 - Membrane interactions of tetradecapeptide toxin mastoparan (MP) and analogues (MP-3, MP-X and polistes MP), as indicated by inhibition of various enzymatic and cellular activities, were investigated. MP-3 was found to be the least active in inhibiting protein kinase C (PKC; activated by phosphatidylserine vesicles, synaptosomal membranes or phorbol ester), synaptosomal membrane Na,K-ATPase and proliferation and viability of leukemia HL60 cells. MP-3, however, was as active as others in inhibiting PKC activated by arachidonate monomers and phorbol ester binding. The unique properties of MP-3, the [des-Ile1-Asn2]- analogue of MP, might be related to its low functional amphiphilicity compared to others and useful in further delineating biological activities associated with or regulated by membranes. JF - Febs Letters AD - Emory Univ,Sch Med,Dept Pharmacol,Atlanta,Ga 30322Emory Univ,Sch Med,Dept Med,Atlanta,Ga 30322 EP - 279 TI - Membrane Interactions of Mastoparan Analogs Related to Their Differential-Effects on Protein-Kinase-C, Na,K-Atpase and Hl-60 Cells VL - 307 SP - 275 KW - analogs KW - and KW - bibtex-import KW - mastoparan N1 - Jh396Times Cited:13Cited References Count:24 AU - Raynor, RL AU - Kim, YS AU - Bin, Z AU - Vogler, WR AU - Kuo, JF PY - 1992/// UR - # ER -