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RNA polymerase II stalling: loading at the start prepares genes for a sprint Export

Genome Biology, Vol. 9, No. 5. (02 May 2008), 220.

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rate-limiting_control review rna_pol_ii rna_pol_ii_stalling transcription_elongation

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Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received.


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