Genome-wide RNA polymerase II: not genes only! Export

@article{citeulike:3081904, abstract = {RNA polymerase (Pol) II transcriptional regulation is an essential process for guiding eukaryotic gene expression. Early in vitro studies deciphered the essential steps for transcription, including recruitment, initiation, elongation and termination. Based on these findings, the idea emerged that Pol II should essentially be located on promoters or genic regions of transcribed genes. The development of in vivo localization protocols has enabled the investigation of genome-wide Pol II occupancy. Recent studies from yeast to human show that Pol II can be poised at the transcription start site or can be located outside of gene-coding regions, sometimes dependent on the growth or differentiation stage. These recent results regarding Pol II genomic location and transcription challenge our classical views of transcriptional regulation.}, author = {Koch, Frederic and Jourquin, Frederic and Ferrier, Pierre and Andrau, Jean-Christophe}, citeulike-article-id = {3081904}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tibs.2008.04.006}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18467100}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18467100}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6TCV-4SFK1JR-2/2/8c84031adf24af7ca573ba2f6db4e2cc}, doi = {10.1016/j.tibs.2008.04.006}, journal = {Trends in Biochemical Sciences}, keywords = {pol\_ii\_enhancer\_binding, prpp, review, rna\_pol\_ii, transcription, transcription\_elongation, transcription\_initiation, transcription\_regulation}, month = {June}, number = {6}, pages = {265--273}, posted-at = {2009-03-09 14:38:42}, priority = {0}, title = {Genome-wide RNA polymerase II: not genes only!}, url = {http://dx.doi.org/10.1016/j.tibs.2008.04.006}, volume = {33}, year = {2008} }

TY - JOUR ID - citeulike:3081904 L3 - citeulike-article-id:3081904 N2 - RNA polymerase (Pol) II transcriptional regulation is an essential process for guiding eukaryotic gene expression. Early in vitro studies deciphered the essential steps for transcription, including recruitment, initiation, elongation and termination. Based on these findings, the idea emerged that Pol II should essentially be located on promoters or genic regions of transcribed genes. The development of in vivo localization protocols has enabled the investigation of genome-wide Pol II occupancy. Recent studies from yeast to human show that Pol II can be poised at the transcription start site or can be located outside of gene-coding regions, sometimes dependent on the growth or differentiation stage. These recent results regarding Pol II genomic location and transcription challenge our classical views of transcriptional regulation. IS - 6 JF - Trends in Biochemical Sciences EP - 273 TI - Genome-wide RNA polymerase II: not genes only! VL - 33 SP - 265 KW - pol_ii_enhancer_binding KW - prpp KW - review KW - rna_pol_ii KW - transcription KW - transcription_elongation KW - transcription_initiation KW - transcription_regulation AU - Koch, Frederic AU - Jourquin, Frederic AU - Ferrier, Pierre AU - Andrau, Jean-Christophe PY - 2008/06// UR - http://dx.doi.org/10.1016/j.tibs.2008.04.006 ER -