Depression, heart rate variability, and acute myocardial infarction. Export

@article{Car01, abstract = {BACKGROUND: Clinical depression is associated with an increased risk for mortality in patients with a recent myocardial infarction (MI). Reduced heart rate variability (HRV) has been suggested as a possible explanation for this association. The purpose of this study was to determine if depression is associated with reduced HRV in patients with a recent MI. METHODS AND RESULTS: Three hundred eighty acute MI patients with depression and 424 acute MI patients without depression were recruited. All underwent 24-hour ambulatory electrocardiographic monitoring after hospital discharge. In univariate analyses, 4 indices of HRV were significantly lower in patients with depression than in patients without depression. Variables associated with HRV were then compared between patients with and without depression, and potential confounds were identified. These variables (age, sex, diabetes, and present cigarette smoking) were entered into an analysis of covariance model, followed by depression status. In the final model, all but one HRV index (high-frequency power) remained significantly lower in patients with depression than in patients without depression. CONCLUSIONS: We conclude that greater autonomic dysfunction, as reflected by decreased HRV, is a plausible mechanism linking depression to increased cardiac mortality in post-MI patients.}, address = {Departments of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. carneyr@bmc.wustl.edu}, author = {Carney, R. M. and Blumenthal, J. A. and Stein, P. K. and Watkins, L. and Catellier, D. and Berkman, L. F. and Czajkowski, S. M. and O'Connor, C. and Stone, P. H. and Freedland, K. E.}, citeulike-article-id = {2369172}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11673340}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11673340}, day = {23}, issn = {1524-4539}, journal = {Circulation}, keywords = {cardiac, depression, hrv, ngd, psychophysiological}, month = {October}, number = {17}, pages = {2024--2028}, posted-at = {2008-02-13 10:12:06}, priority = {2}, title = {Depression, heart rate variability, and acute myocardial infarction.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11673340}, volume = {104}, year = {2001} }

TY - JOUR ID - Car01 L3 - citeulike-article-id:2369172 N2 - BACKGROUND: Clinical depression is associated with an increased risk for mortality in patients with a recent myocardial infarction (MI). Reduced heart rate variability (HRV) has been suggested as a possible explanation for this association. The purpose of this study was to determine if depression is associated with reduced HRV in patients with a recent MI. METHODS AND RESULTS: Three hundred eighty acute MI patients with depression and 424 acute MI patients without depression were recruited. All underwent 24-hour ambulatory electrocardiographic monitoring after hospital discharge. In univariate analyses, 4 indices of HRV were significantly lower in patients with depression than in patients without depression. Variables associated with HRV were then compared between patients with and without depression, and potential confounds were identified. These variables (age, sex, diabetes, and present cigarette smoking) were entered into an analysis of covariance model, followed by depression status. In the final model, all but one HRV index (high-frequency power) remained significantly lower in patients with depression than in patients without depression. CONCLUSIONS: We conclude that greater autonomic dysfunction, as reflected by decreased HRV, is a plausible mechanism linking depression to increased cardiac mortality in post-MI patients. IS - 17 JF - Circulation SN - 1524-4539 AD - Departments of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. carneyr@bmc.wustl.edu EP - 2028 TI - Depression, heart rate variability, and acute myocardial infarction. VL - 104 SP - 2024 KW - cardiac KW - depression KW - hrv KW - ngd KW - psychophysiological AU - Carney, RM AU - Blumenthal, JA AU - Stein, PK AU - Watkins, L AU - Catellier, D AU - Berkman, LF AU - Czajkowski, SM AU - O'Connor, C AU - Stone, PH AU - Freedland, KE PY - 2001/10/23/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11673340 ER -