Stromal effects on mammary gland development and breast cancer. Export

@article{citeulike:1729103, abstract = {Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here we review our present knowledge of the specific factors and cell types that contribute to epithelial-stromal crosstalk during mammary development. To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other.}, author = {Wiseman, Bryony S. and Werb, Zena}, citeulike-article-id = {1729103}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1067431}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/296/5570/1046}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12004111}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12004111}, day = {10}, doi = {10.1126/science.1067431}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {cancer, microenvironment}, month = {May}, number = {5570}, pages = {1046--1049}, posted-at = {2009-10-31 01:12:54}, priority = {2}, title = {Stromal effects on mammary gland development and breast cancer.}, url = {http://dx.doi.org/10.1126/science.1067431}, volume = {296}, year = {2002} }

TY - JOUR ID - citeulike:1729103 L3 - citeulike-article-id:1729103 N2 - Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here we review our present knowledge of the specific factors and cell types that contribute to epithelial-stromal crosstalk during mammary development. To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other. IS - 5570 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1049 TI - Stromal effects on mammary gland development and breast cancer. VL - 296 SP - 1046 KW - cancer KW - microenvironment AU - Wiseman, Bryony AU - Werb, Zena PY - 2002/05/10/ UR - http://dx.doi.org/10.1126/science.1067431 ER -