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Intravital imaging of metastatic behavior through a mammary imaging window Export

Nature Methods, Vol. 5, No. 12. (09 November 2008), pp. 1019-1021.

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cancer imaging mammary metastasis microenvironment

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The combination of a glass window placed on top of a mouse mammary gland with photoswitchable fluorescent protein labeling of implanted tumor cells allows tumor-cell tracking over multiple imaging sessions in orthotopic tumors. Results show the existence of two distinct microenvironments with different tumor-cell invasion and intravasation characteristics.


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