Microenvironmental regulation of metastasis. Export

@article{citeulike:4219531, abstract = {Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues.}, author = {Joyce, Johanna A. and Pollard, Jeffrey W.}, citeulike-article-id = {4219531}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrc2618}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrc2618}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19279573}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19279573}, day = {12}, doi = {10.1038/nrc2618}, issn = {1474-1768}, journal = {Nature reviews. Cancer}, keywords = {biology, microenvironment, tumor}, month = {April}, number = {4}, pages = {239--252}, posted-at = {2009-04-04 17:22:26}, priority = {2}, publisher = {Nature Publishing Group}, title = {Microenvironmental regulation of metastasis.}, url = {http://dx.doi.org/10.1038/nrc2618}, volume = {9}, year = {2009} }

TY - JOUR ID - citeulike:4219531 L3 - citeulike-article-id:4219531 N2 - Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues. IS - 4 JF - Nature reviews. Cancer SN - 1474-1768 EP - 252 TI - Microenvironmental regulation of metastasis. PB - Nature Publishing Group VL - 9 SP - 239 KW - biology KW - microenvironment KW - tumor AU - Joyce, Johanna AU - Pollard, Jeffrey PY - 2009/04/12/ UR - http://dx.doi.org/10.1038/nrc2618 ER -