Effects of inhaled furosemide on exertional dyspnea in chronic obstructive pulmonary disease. Export

@article{citeulike:259764, abstract = {The aim of this study is to investigate the effects of inhaled furosemide on the sensation of dyspnea produced during exercise in patients with stable chronic obstructive pulmonary disease (COPD). In a double-blind, randomized, crossover study we compared the effect of inhaled furosemide on dyspneic sensation during exercise testing with that of placebo. Spirometry and incremental and constant-load exercise testing were performed after inhalation of placebo or furosemide on 2 separate days in 19 patients with moderate or severe COPD. Subjects were asked to rate their sensation of respiratory discomfort using a 100-mm visual analog scale. There was significant improvement in mean FEV1 and FVC after inhalation of furosemide (p = 0.038 and 0.005, respectively) but not after placebo. At standardized exercise time during constant-load exercise testing but not during incremental exercise, the mean dyspneic visual analog scale score was lower after inhalation of furosemide compared with placebo (33.7 +/- 25.2 vs. 42.4 +/- 24.0 mm, respectively, p = 0.014). We conclude that inhalation of furosemide alleviates the sensation of dyspnea induced by constant-load exercise testing in patients with COPD and that there is significant bronchodilation after inhalation of furosemide compared with placebo in these patients.}, address = {Department of Respiratory Medicine and Clinical Research Unit, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433. kian\_chung\_ong@ttsh.com.sg}, author = {Ong, K. C. and Kor, A. C. and Chong, W. F. and Earnest, A. and Wang, Y. T.}, citeulike-article-id = {259764}, citeulike-linkout-0 = {http://dx.doi.org/10.1164/rccm.200308-1171OC}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14977622}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14977622}, day = {1}, doi = {10.1164/rccm.200308-1171OC}, issn = {1073-449X}, journal = {Am J Respir Crit Care Med}, keywords = {copd, pulmonology}, month = {May}, number = {9}, pages = {1028--1033}, posted-at = {2005-07-20 06:07:16}, priority = {5}, title = {Effects of inhaled furosemide on exertional dyspnea in chronic obstructive pulmonary disease.}, url = {http://dx.doi.org/10.1164/rccm.200308-1171OC}, volume = {169}, year = {2004} }

TY - JOUR ID - citeulike:259764 L3 - citeulike-article-id:259764 N2 - The aim of this study is to investigate the effects of inhaled furosemide on the sensation of dyspnea produced during exercise in patients with stable chronic obstructive pulmonary disease (COPD). In a double-blind, randomized, crossover study we compared the effect of inhaled furosemide on dyspneic sensation during exercise testing with that of placebo. Spirometry and incremental and constant-load exercise testing were performed after inhalation of placebo or furosemide on 2 separate days in 19 patients with moderate or severe COPD. Subjects were asked to rate their sensation of respiratory discomfort using a 100-mm visual analog scale. There was significant improvement in mean FEV1 and FVC after inhalation of furosemide (p = 0.038 and 0.005, respectively) but not after placebo. At standardized exercise time during constant-load exercise testing but not during incremental exercise, the mean dyspneic visual analog scale score was lower after inhalation of furosemide compared with placebo (33.7 +/- 25.2 vs. 42.4 +/- 24.0 mm, respectively, p = 0.014). We conclude that inhalation of furosemide alleviates the sensation of dyspnea induced by constant-load exercise testing in patients with COPD and that there is significant bronchodilation after inhalation of furosemide compared with placebo in these patients. IS - 9 JF - Am J Respir Crit Care Med SN - 1073-449X AD - Department of Respiratory Medicine and Clinical Research Unit, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433. kian_chung_ong@ttsh.com.sg EP - 1033 TI - Effects of inhaled furosemide on exertional dyspnea in chronic obstructive pulmonary disease. VL - 169 SP - 1028 KW - copd KW - pulmonology AU - Ong, KC AU - Kor, AC AU - Chong, WF AU - Earnest, A AU - Wang, YT PY - 2004/05/01/ UR - http://dx.doi.org/10.1164/rccm.200308-1171OC ER -