Use of low- and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs. Export

@article{citeulike:1444847, abstract = {OBJECTIVE--To evaluate low- and high-dose dexamethasone suppression tests for differentiating pituitary dependent hyperadrenocorticism (PDH) from adrenal tumor hyperadrenocorticism (ATH) in dogs. DESIGN--Prospective study. ANIMALS--181 dogs with PDH and 35 dogs with ATH. PROCEDURE--Plasma cortisol concentrations from dogs with naturally developing hyperadrenocorticism were evaluated before, and 4 and 8 hours after administration of standard low- and high-doses of dexamethasone (0.01 mg/kg of body weight, i.v., and 0.1 mg/kg, i.v.; respectively). RESULTS--In response to the low-dose test, all but 3 dogs had an 8-hours post-dexamethasone plasma cortisol concentration that was consistent with a diagnosis of hyperadrenocorticism, that is, > or = 1.4 micrograms/dl. Criteria used to distinguish PDH from ATH in response to low-dose dexamethasone included a 4-hour post-dexamethasone plasma cortisol concentration < 50\% of the basal value or < 1.4 micrograms/dl, or an 8-hours post-dexamethasone plasma cortisol concentration < 50\% of the basal concentration. Criteria used to distinguish PDH from ATH in response to high-dose dexamethasone included 4- or 8-hour post-dexamethasone plasma cortisol concentrations < 50\% of the basal concentration or < 1.4 micrograms/dl. In response to the low-dose test, 111 dogs met criteria for suppression (each had PDH). In response to the high-dose test, 137 dogs met criteria for suppression (2 had ATH, 135 had PDH). Twenty-six dogs with PDH (12\%) had indications of adrenal suppression in response to high-dose but not low-dose testing. CLINICAL IMPLICATIONS--Low-dose dexamethasone test has value as a discrimination test to distinguish dogs with PDH from those with ATH. The high-dose test need only be considered in dogs with hyperadrenocorticism that do not have adrenal suppression in response to the low-dose test.}, address = {Department of Medicine, University of California, Davis 95616, USA.}, author = {Feldman, E. C. and Nelson, R. W. and Feldman, M. S.}, citeulike-article-id = {1444847}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8756877}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8756877}, day = {15}, issn = {0003-1488}, journal = {J Am Vet Med Assoc}, keywords = {adrenal, cancer, dog}, month = {August}, number = {4}, pages = {772--775}, posted-at = {2007-07-09 22:07:08}, priority = {2}, title = {Use of low- and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8756877}, volume = {209}, year = {1996} }

TY - JOUR ID - citeulike:1444847 L3 - citeulike-article-id:1444847 N2 - OBJECTIVE--To evaluate low- and high-dose dexamethasone suppression tests for differentiating pituitary dependent hyperadrenocorticism (PDH) from adrenal tumor hyperadrenocorticism (ATH) in dogs. DESIGN--Prospective study. ANIMALS--181 dogs with PDH and 35 dogs with ATH. PROCEDURE--Plasma cortisol concentrations from dogs with naturally developing hyperadrenocorticism were evaluated before, and 4 and 8 hours after administration of standard low- and high-doses of dexamethasone (0.01 mg/kg of body weight, i.v., and 0.1 mg/kg, i.v.; respectively). RESULTS--In response to the low-dose test, all but 3 dogs had an 8-hours post-dexamethasone plasma cortisol concentration that was consistent with a diagnosis of hyperadrenocorticism, that is, > or = 1.4 micrograms/dl. Criteria used to distinguish PDH from ATH in response to low-dose dexamethasone included a 4-hour post-dexamethasone plasma cortisol concentration < 50% of the basal value or < 1.4 micrograms/dl, or an 8-hours post-dexamethasone plasma cortisol concentration < 50% of the basal concentration. Criteria used to distinguish PDH from ATH in response to high-dose dexamethasone included 4- or 8-hour post-dexamethasone plasma cortisol concentrations < 50% of the basal concentration or < 1.4 micrograms/dl. In response to the low-dose test, 111 dogs met criteria for suppression (each had PDH). In response to the high-dose test, 137 dogs met criteria for suppression (2 had ATH, 135 had PDH). Twenty-six dogs with PDH (12%) had indications of adrenal suppression in response to high-dose but not low-dose testing. CLINICAL IMPLICATIONS--Low-dose dexamethasone test has value as a discrimination test to distinguish dogs with PDH from those with ATH. The high-dose test need only be considered in dogs with hyperadrenocorticism that do not have adrenal suppression in response to the low-dose test. IS - 4 JF - J Am Vet Med Assoc SN - 0003-1488 AD - Department of Medicine, University of California, Davis 95616, USA. EP - 775 TI - Use of low- and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs. VL - 209 SP - 772 KW - adrenal KW - cancer KW - dog AU - Feldman, EC AU - Nelson, RW AU - Feldman, MS PY - 1996/08/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8756877 ER -