The effects of stenting and endothelial denudation on aneurysm and branch occlusion in experimental aneurysm models. Export

@article{citeulike:1471654, abstract = {BACKGROUND: Stents are increasingly used in the endovascular treatment of intracranial aneurysms. We studied the effects of stenting and endothelial denudation on aneurysm and branch vessel occlusion. METHODS: Bilateral lingual bifurcation venous pouch aneurysms were created in eight dogs, surgically scraping the aneurysmal endothelial lining on one side. Both arteries were immediately stented using balloon-expandable stents. In four other dogs, a wide-neck carotid bifurcation aneurysm was created, with the vein pouch denuded or not (n=2 each), followed by immediate stenting. Results were compared using angiography and pathology at 10 days (n=2), 10 (n=8), and 20 weeks (n=2). Branch occlusion between initial and final angiograms was recorded. Pathological evaluation of aneurysms was studied, with attention to neointima formation at the aneurysm ostium and around branch vessel origins. RESULTS: All stented and denuded lingual aneurysms were obliterated compared with two of eight lingual aneurysms that were stented alone (P=.007). None of the carotid bifurcation aneurysms became obliterated (0/4), but denuded aneurysms showed partial thrombosis (2/2). Of 68 total stent-covered branches, 5 (7\%) were occluded and 17 (27\%) had altered angiographic flow. CONCLUSIONS: Stenting led to suboptimal results in the presence of an intact endothelial layer. Endothelial denudation can promote aneurysm occlusion when combined with stenting.}, address = {CHUM Notre-Dame Hospital, Montreal, Quebec, Canada.}, author = {Darsaut, T. and Bouzeghrane, F. and Salazkin, I. and Lerouge, S. and Soulez, G. and Gevry, G. and Raymond, J.}, citeulike-article-id = {1471654}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jvs.2007.02.060}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17543687}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17543687}, doi = {10.1016/j.jvs.2007.02.060}, issn = {0741-5214}, journal = {J Vasc Surg}, keywords = {aneurysm, dog, experimental, stent, vascular}, month = {June}, number = {6}, pages = {1228--1235}, posted-at = {2007-07-21 17:36:40}, priority = {2}, title = {The effects of stenting and endothelial denudation on aneurysm and branch occlusion in experimental aneurysm models.}, url = {http://dx.doi.org/10.1016/j.jvs.2007.02.060}, volume = {45}, year = {2007} }

TY - JOUR ID - citeulike:1471654 L3 - citeulike-article-id:1471654 N2 - BACKGROUND: Stents are increasingly used in the endovascular treatment of intracranial aneurysms. We studied the effects of stenting and endothelial denudation on aneurysm and branch vessel occlusion. METHODS: Bilateral lingual bifurcation venous pouch aneurysms were created in eight dogs, surgically scraping the aneurysmal endothelial lining on one side. Both arteries were immediately stented using balloon-expandable stents. In four other dogs, a wide-neck carotid bifurcation aneurysm was created, with the vein pouch denuded or not (n=2 each), followed by immediate stenting. Results were compared using angiography and pathology at 10 days (n=2), 10 (n=8), and 20 weeks (n=2). Branch occlusion between initial and final angiograms was recorded. Pathological evaluation of aneurysms was studied, with attention to neointima formation at the aneurysm ostium and around branch vessel origins. RESULTS: All stented and denuded lingual aneurysms were obliterated compared with two of eight lingual aneurysms that were stented alone (P=.007). None of the carotid bifurcation aneurysms became obliterated (0/4), but denuded aneurysms showed partial thrombosis (2/2). Of 68 total stent-covered branches, 5 (7%) were occluded and 17 (27%) had altered angiographic flow. CONCLUSIONS: Stenting led to suboptimal results in the presence of an intact endothelial layer. Endothelial denudation can promote aneurysm occlusion when combined with stenting. IS - 6 JF - J Vasc Surg SN - 0741-5214 AD - CHUM Notre-Dame Hospital, Montreal, Quebec, Canada. EP - 1235 TI - The effects of stenting and endothelial denudation on aneurysm and branch occlusion in experimental aneurysm models. VL - 45 SP - 1228 KW - aneurysm KW - dog KW - experimental KW - stent KW - vascular AU - Darsaut, T AU - Bouzeghrane, F AU - Salazkin, I AU - Lerouge, S AU - Soulez, G AU - Gevry, G AU - Raymond, J PY - 2007/06// UR - http://dx.doi.org/10.1016/j.jvs.2007.02.060 ER -