Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings.

@article{citeulike:2003906, abstract = {The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.}, address = {Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.}, author = {Kang, B. T. and Lee, J. H. and Jung, D. I. and Park, C. and Gu, S. H. and Jeon, H. W. and Jang, D. P. and Lim, C. Y. and Quan, F. S. and Kim, Y. B. and Cho, Z. H. and Woo, E. J. and Park, H. M. }, citeulike-article-id = {2003906}, issn = {1229-845X}, journal = {J Vet Sci}, keywords = {cerebral-artery, dog, histopathology, ischemic-stroke, model, occlusion}, month = {December}, number = {4}, pages = {369--376}, posted-at = {2007-11-28 13:15:08}, priority = {2}, title = {Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17993751}, volume = {8}, year = {2007} }

TY - JOUR ID - citeulike:2003906 L3 - citeulike-article-id:2003906 TI - Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings. JF - J Vet Sci VL - 8 IS - 4 SP - 369 EP - 376 AD - Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea. SN - 1229-845X N2 - The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients. KW - cerebral-artery KW - dog KW - histopathology KW - ischemic-stroke KW - model KW - occlusion AU - Kang, BT AU - Lee, JH AU - Jung, DI AU - Park, C AU - Gu, SH AU - Jeon, HW AU - Jang, DP AU - Lim, CY AU - Quan, FS AU - Kim, YB AU - Cho, ZH AU - Woo, EJ AU - Park, HM PY - 2007/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/17993751 ER -