Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive poly-L,D-lactide spiral partial ureteral stent: an experimental study. Export

@article{citeulike:2553154, abstract = {PURPOSE: To evaluate the drainage and antireflux characteristics of a new self-expandable self-reinforced poly-L,D-lactide partial ureteral stent (SR-PLA 96) in an experimental model. MATERIALS AND METHODS: Twelve dogs were used as experimental animals. A low-midline laparotomy and cystotomy were performed on all animals. In group A (six animals), 50-mm long SR-PLA 96 ureteral stents with a double-helical spiral design were inserted into both ureters, leaving the lower ends 2 cm above the ureterovesical junction. In group B (six animals), both ureters were stented with traditional pigtail stents (C-Flex) Double-J; Cook Urological), which were removed 8 weeks after surgery. Renal function and ureteral patency were evaluated by dynamic kidney imaging and urography examinations at 6 and 12 weeks postoperatively. The degrees of vesicoureteral reflux at two levels of the ureters and at the level of the renal pelvis were evaluated by nuclear voiding cystograms at 6 weeks. RESULTS: The partial SR-PLA 96 stent design showed more favorable antireflux properties that the Double-J stent design. The degree of vesicoureteral reflux, reflected in an increase of nuclear enhancement at 6 weeks, was lower in the distal (7.9\% +/- 14.7\% v 63.2\% +/- 17.3\%; P < 0.05) and middle (6.1\% +/- 8.1\% v. 45.5\% +/- 19.5\%; P = 0.15) levels of the ureters as well as at the level of the renal pelvis (-3.4\% +/- 3.6\% v 6.2\% +/- 3.9\%; P = 0.65) than in the Double-J-stented ureters. No significant differences in renal function or ureteral patency were observed at 12 weeks after the Double-J stents had been removed and the SR-PLA 96 stents had fragmented. CONCLUSION: A self-expandable, self-reinforced SR-PLA 96 partial ureteral stent showed more favorable antireflux properties than a Double-J stent.}, address = {Department of Surgery, Kuopio University Hospital, Kuopio, Finland. juha.lumiaho@kuh.fi}, author = {Lumiaho, J. and Heino, A. and Kauppinen, T. and Talja, M. and Alhava, E. and V\"{a}limaa, T. and T\"{o}rm\"{a}l\"{a}, P.}, citeulike-article-id = {2553154}, citeulike-linkout-0 = {http://dx.doi.org/10.1089/end.2005.0085}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18186698}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18186698}, doi = {10.1089/end.2005.0085}, issn = {0892-7790}, journal = {J Endourol}, keywords = {antireflux, biodegradable, dog, drainage, experimental, partial, radiography, spiral, stent, ureteral}, month = {December}, number = {12}, pages = {1559--1564}, posted-at = {2008-03-18 23:08:39}, priority = {2}, title = {Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive poly-L,D-lactide spiral partial ureteral stent: an experimental study.}, url = {http://dx.doi.org/10.1089/end.2005.0085}, volume = {21}, year = {2007} }

TY - JOUR ID - citeulike:2553154 L3 - citeulike-article-id:2553154 N2 - PURPOSE: To evaluate the drainage and antireflux characteristics of a new self-expandable self-reinforced poly-L,D-lactide partial ureteral stent (SR-PLA 96) in an experimental model. MATERIALS AND METHODS: Twelve dogs were used as experimental animals. A low-midline laparotomy and cystotomy were performed on all animals. In group A (six animals), 50-mm long SR-PLA 96 ureteral stents with a double-helical spiral design were inserted into both ureters, leaving the lower ends 2 cm above the ureterovesical junction. In group B (six animals), both ureters were stented with traditional pigtail stents (C-Flex) Double-J; Cook Urological), which were removed 8 weeks after surgery. Renal function and ureteral patency were evaluated by dynamic kidney imaging and urography examinations at 6 and 12 weeks postoperatively. The degrees of vesicoureteral reflux at two levels of the ureters and at the level of the renal pelvis were evaluated by nuclear voiding cystograms at 6 weeks. RESULTS: The partial SR-PLA 96 stent design showed more favorable antireflux properties that the Double-J stent design. The degree of vesicoureteral reflux, reflected in an increase of nuclear enhancement at 6 weeks, was lower in the distal (7.9% +/- 14.7% v 63.2% +/- 17.3%; P < 0.05) and middle (6.1% +/- 8.1% v. 45.5% +/- 19.5%; P = 0.15) levels of the ureters as well as at the level of the renal pelvis (-3.4% +/- 3.6% v 6.2% +/- 3.9%; P = 0.65) than in the Double-J-stented ureters. No significant differences in renal function or ureteral patency were observed at 12 weeks after the Double-J stents had been removed and the SR-PLA 96 stents had fragmented. CONCLUSION: A self-expandable, self-reinforced SR-PLA 96 partial ureteral stent showed more favorable antireflux properties than a Double-J stent. IS - 12 JF - J Endourol SN - 0892-7790 AD - Department of Surgery, Kuopio University Hospital, Kuopio, Finland. juha.lumiaho@kuh.fi EP - 1564 TI - Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive poly-L,D-lactide spiral partial ureteral stent: an experimental study. VL - 21 SP - 1559 KW - antireflux KW - biodegradable KW - dog KW - drainage KW - experimental KW - partial KW - radiography KW - spiral KW - stent KW - ureteral AU - Lumiaho, J AU - Heino, A AU - Kauppinen, T AU - Talja, M AU - Alhava, E AU - Välimaa, T AU - Törmälä, P PY - 2007/12// UR - http://dx.doi.org/10.1089/end.2005.0085 ER -