Chemically based mathematical model for development of cerebral cortical folding patterns. Export

@article{citeulike:5865078, abstract = {The mechanism for cortical folding pattern formation is not fully understood. Current models represent scenarios that describe pattern formation through local interactions, and one recent model is the intermediate progenitor model. The intermediate progenitor (IP) model describes a local chemically driven scenario, where an increase in intermediate progenitor cells in the subventricular zone correlates to gyral formation. Here we present a mathematical model that uses features of the IP model and further captures global characteristics of cortical pattern formation. A prolate spheroidal surface is used to approximate the ventricular zone. Prolate spheroidal harmonics are applied to a Turing reaction-diffusion system, providing a chemically based framework for cortical folding. Our model reveals a direct correlation between pattern formation and the size and shape of the lateral ventricle. Additionally, placement and directionality of sulci and the relationship between domain scaling and cortical pattern elaboration are explained. The significance of this model is that it elucidates the consistency of cortical patterns among individuals within a species and addresses inter-species variability based on global characteristics and provides a critical piece to the puzzle of cortical pattern formation.}, author = {Striegel, Deborah A. and Hurdal, Monica K.}, citeulike-article-id = {5865078}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pcbi.1000524}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19779554}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19779554}, day = {25}, doi = {10.1371/journal.pcbi.1000524}, issn = {1553-7358}, journal = {PLoS computational biology}, keywords = {cortical-folding, development, morphogenesis, turing, wiring}, month = {September}, number = {9}, pages = {e1000524+}, posted-at = {2009-10-01 09:33:15}, priority = {0}, publisher = {Public Library of Science}, title = {Chemically based mathematical model for development of cerebral cortical folding patterns.}, url = {http://dx.doi.org/10.1371/journal.pcbi.1000524}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5865078 L3 - citeulike-article-id:5865078 N2 - The mechanism for cortical folding pattern formation is not fully understood. Current models represent scenarios that describe pattern formation through local interactions, and one recent model is the intermediate progenitor model. The intermediate progenitor (IP) model describes a local chemically driven scenario, where an increase in intermediate progenitor cells in the subventricular zone correlates to gyral formation. Here we present a mathematical model that uses features of the IP model and further captures global characteristics of cortical pattern formation. A prolate spheroidal surface is used to approximate the ventricular zone. Prolate spheroidal harmonics are applied to a Turing reaction-diffusion system, providing a chemically based framework for cortical folding. Our model reveals a direct correlation between pattern formation and the size and shape of the lateral ventricle. Additionally, placement and directionality of sulci and the relationship between domain scaling and cortical pattern elaboration are explained. The significance of this model is that it elucidates the consistency of cortical patterns among individuals within a species and addresses inter-species variability based on global characteristics and provides a critical piece to the puzzle of cortical pattern formation. IS - 9 JF - PLoS computational biology SN - 1553-7358 TI - Chemically based mathematical model for development of cerebral cortical folding patterns. PB - Public Library of Science VL - 5 SP - e1000524 KW - cortical-folding KW - development KW - morphogenesis KW - turing KW - wiring AU - Striegel, Deborah AU - Hurdal, Monica PY - 2009/09/25/ UR - http://dx.doi.org/10.1371/journal.pcbi.1000524 ER -