Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Export

@article{citeulike:789757, abstract = {Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and 5-HT uptake in lymphoblasts. Association studies in two independent samples totaling 505 individuals revealed that the 5-HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in anxiety-related personality traits in individuals as well as sibships.}, address = {Department of Psychiatry, University of W\"{u}rzburg, F\"{u}chsleinstrasse 15, 97080 W\"{u}rzburg, Germany. kplesch@rzbox.uni-wuerzburg.de}, author = {Lesch, K. P. and Bengel, D. and Heils, A. and Sabol, S. Z. and Greenberg, B. D. and Petri, S. and Benjamin, J. and M\"{u}ller, C. R. and Hamer, D. H. and Murphy, D. L.}, citeulike-article-id = {789757}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.274.5292.1527}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/274/5292/1527}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/8929413}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=8929413}, day = {29}, doi = {10.1126/science.274.5292.1527}, issn = {0036-8075}, journal = {Science (New York, N.Y.)}, keywords = {5-htt, anxiety, disease, mapping}, month = {November}, number = {5292}, pages = {1527--1531}, posted-at = {2008-06-09 18:01:41}, priority = {0}, title = {Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.}, url = {http://dx.doi.org/10.1126/science.274.5292.1527}, volume = {274}, year = {1996} }

TY - JOUR ID - citeulike:789757 L3 - citeulike-article-id:789757 N2 - Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and 5-HT uptake in lymphoblasts. Association studies in two independent samples totaling 505 individuals revealed that the 5-HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in anxiety-related personality traits in individuals as well as sibships. IS - 5292 JF - Science (New York, N.Y.) SN - 0036-8075 AD - Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany. kplesch@rzbox.uni-wuerzburg.de EP - 1531 TI - Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. VL - 274 SP - 1527 KW - 5-htt KW - anxiety KW - disease KW - mapping AU - Lesch, KP AU - Bengel, D AU - Heils, A AU - Sabol, SZ AU - Greenberg, BD AU - Petri, S AU - Benjamin, J AU - Müller, CR AU - Hamer, DH AU - Murphy, DL PY - 1996/11/29/ UR - http://dx.doi.org/10.1126/science.274.5292.1527 ER -