Dynamics and mechanics of the microtubule plus end Export

@article{Howard&Hyman_Nature2003, abstract = {An important function of microtubules is to move cellular structures such as chromosomes, mitotic spindles and other organelles around inside cells. This is achieved by attaching the ends of microtubules to cellular structures; as the microtubules grow and shrink, the structures are pushed or pulled around the cell. How do the ends of microtubules couple to cellular structures, and how does this coupling regulate the stability and distribution of the microtubules? It is now clear that there are at least three properties of a microtubule end: it has alternate structures; it has a biochemical transition defined by GTP hydrolysis; and it forms a distinct target for the binding of specific proteins. These different properties can be unified by thinking of the microtubule as a molecular machine, which switches between growing and shrinking modes. Each mode is associated with a specific end structure on which end-binding proteins can assemble to modulate dynamics and couple the dynamic properties of microtubules to the movement of cellular structures.}, address = {Max Plank Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, 01307 Dresden, Germany.}, author = {Howard, Joe and Hyman, Anthony A.}, citeulike-article-id = {112794}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature01600}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature01600}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12700769}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12700769}, day = {17}, doi = {10.1038/nature01600}, issn = {0028-0836}, journal = {Nature}, keywords = {2003, and, dynamicsplus, end, howard, hyman, microtbule, nature, review}, month = {April}, number = {6933}, pages = {753--758}, posted-at = {2008-05-23 16:12:43}, priority = {0}, title = {Dynamics and mechanics of the microtubule plus end}, url = {http://dx.doi.org/10.1038/nature01600}, volume = {422}, year = {2003} }

TY - JOUR ID - Howard&Hyman_Nature2003 L3 - citeulike-article-id:112794 N2 - An important function of microtubules is to move cellular structures such as chromosomes, mitotic spindles and other organelles around inside cells. This is achieved by attaching the ends of microtubules to cellular structures; as the microtubules grow and shrink, the structures are pushed or pulled around the cell. How do the ends of microtubules couple to cellular structures, and how does this coupling regulate the stability and distribution of the microtubules? It is now clear that there are at least three properties of a microtubule end: it has alternate structures; it has a biochemical transition defined by GTP hydrolysis; and it forms a distinct target for the binding of specific proteins. These different properties can be unified by thinking of the microtubule as a molecular machine, which switches between growing and shrinking modes. Each mode is associated with a specific end structure on which end-binding proteins can assemble to modulate dynamics and couple the dynamic properties of microtubules to the movement of cellular structures. IS - 6933 JF - Nature SN - 0028-0836 AD - Max Plank Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, 01307 Dresden, Germany. EP - 758 TI - Dynamics and mechanics of the microtubule plus end VL - 422 SP - 753 KW - 2003 KW - and KW - dynamicsplus KW - end KW - howard KW - hyman KW - microtbule KW - nature KW - review AU - Howard, Joe AU - Hyman, Anthony PY - 2003/04/17/ UR - http://dx.doi.org/10.1038/nature01600 ER -