Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope. Export

@article{KoszulR_MeioticChromMovement_Cell_2008, abstract = {Chromosome movement is prominent during meiosis. Here, using a combination of in vitro and in vivo approaches, we elucidate the basis for dynamic mid-prophase telomere-led chromosome motion in budding yeast. Diverse findings reveal a process in which, at the pachytene stage, individual telomere/nuclear envelope (NE) ensembles attach passively to, and then move in concert with, nucleus-hugging actin cables that are continuous with the global cytoskeletal actin network. Other chromosomes move in concert with lead chromosome(s). The same process, in modulated form, explains the zygotene "bouquet" configuration in which, immediately preceding pachytene, chromosome ends colocalize dynamically in a restricted region of the NE. Mechanical properties of the system and biological roles of mid-prophase movement for meiosis, including recombination, are discussed.}, author = {Koszul, R. and Kim, K. P. and Prentiss, M. and Kleckner, N. and Kameoka, S.}, citeulike-article-id = {3385819}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2008.04.050}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18585353}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18585353}, day = {27}, doi = {10.1016/j.cell.2008.04.050}, issn = {1097-4172}, journal = {Cell}, keywords = {actin, chromosome, meiotic, movement, prophase, telomere}, month = {June}, number = {7}, pages = {1188--1201}, posted-at = {2008-10-08 11:08:13}, priority = {0}, title = {Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope.}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.050}, volume = {133}, year = {2008} }

TY - JOUR ID - KoszulR_MeioticChromMovement_Cell_2008 L3 - citeulike-article-id:3385819 N2 - Chromosome movement is prominent during meiosis. Here, using a combination of in vitro and in vivo approaches, we elucidate the basis for dynamic mid-prophase telomere-led chromosome motion in budding yeast. Diverse findings reveal a process in which, at the pachytene stage, individual telomere/nuclear envelope (NE) ensembles attach passively to, and then move in concert with, nucleus-hugging actin cables that are continuous with the global cytoskeletal actin network. Other chromosomes move in concert with lead chromosome(s). The same process, in modulated form, explains the zygotene "bouquet" configuration in which, immediately preceding pachytene, chromosome ends colocalize dynamically in a restricted region of the NE. Mechanical properties of the system and biological roles of mid-prophase movement for meiosis, including recombination, are discussed. IS - 7 JF - Cell SN - 1097-4172 EP - 1201 TI - Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope. VL - 133 SP - 1188 KW - actin KW - chromosome KW - meiotic KW - movement KW - prophase KW - telomere AU - Koszul, R AU - Kim, KP AU - Prentiss, M AU - Kleckner, N AU - Kameoka, S PY - 2008/06/27/ UR - http://dx.doi.org/10.1016/j.cell.2008.04.050 ER -