Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Export

@article{ConradMN_MeioticTelomMovem_Cell_2008, abstract = {Haploidization of the genome in meiosis requires that chromosomes be sorted exclusively into pairs stabilized by synaptonemal complexes (SCs) and crossovers. This sorting and pairing is accompanied by active chromosome positioning in meiotic prophase in which telomeres cluster near the spindle pole to form the bouquet before dispersing around the nuclear envelope. We now describe telomere-led rapid prophase movements (RPMs) that frequently exceed 1 microm/s and persist throughout meiotic prophase. Bouquet formation and RPMs depend on NDJ1, MPS3, and a new member of this pathway, CSM4, which encodes a meiosis-specific nuclear envelope protein required specifically for telomere mobility. RPMs initiate independently of recombination but differ quantitatively in mutants that fail to complete recombination, suggesting that RPMs respond to recombination status. Together with recombination defects described for ndj1, our observations suggest that RPMs and SCs balance the disruption and stabilization of recombinational interactions, respectively, to regulate crossing over.}, author = {Conrad, M. N. and Lee, C. Y. and Chao, G. and Shinohara, M. and Kosaka, H. and Shinohara, A. and Conchello, J. A. and Dresser, M. E.}, citeulike-article-id = {3385851}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2008.04.047}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18585352}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18585352}, day = {27}, doi = {10.1016/j.cell.2008.04.047}, issn = {1097-4172}, journal = {Cell}, keywords = {actin, chromosome, movment, telomere, yeast}, month = {June}, number = {7}, pages = {1175--1187}, posted-at = {2008-10-08 11:22:20}, priority = {0}, title = {Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination.}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.047}, volume = {133}, year = {2008} }

TY - JOUR ID - ConradMN_MeioticTelomMovem_Cell_2008 L3 - citeulike-article-id:3385851 N2 - Haploidization of the genome in meiosis requires that chromosomes be sorted exclusively into pairs stabilized by synaptonemal complexes (SCs) and crossovers. This sorting and pairing is accompanied by active chromosome positioning in meiotic prophase in which telomeres cluster near the spindle pole to form the bouquet before dispersing around the nuclear envelope. We now describe telomere-led rapid prophase movements (RPMs) that frequently exceed 1 microm/s and persist throughout meiotic prophase. Bouquet formation and RPMs depend on NDJ1, MPS3, and a new member of this pathway, CSM4, which encodes a meiosis-specific nuclear envelope protein required specifically for telomere mobility. RPMs initiate independently of recombination but differ quantitatively in mutants that fail to complete recombination, suggesting that RPMs respond to recombination status. Together with recombination defects described for ndj1, our observations suggest that RPMs and SCs balance the disruption and stabilization of recombinational interactions, respectively, to regulate crossing over. IS - 7 JF - Cell SN - 1097-4172 EP - 1187 TI - Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. VL - 133 SP - 1175 KW - actin KW - chromosome KW - movment KW - telomere KW - yeast AU - Conrad, MN AU - Lee, CY AU - Chao, G AU - Shinohara, M AU - Kosaka, H AU - Shinohara, A AU - Conchello, JA AU - Dresser, ME PY - 2008/06/27/ UR - http://dx.doi.org/10.1016/j.cell.2008.04.047 ER -