Converging concepts of protein folding in vitro and in vivo Export

@article{citeulike:4733200, abstract = {Most proteins must fold into precise three-dimensional conformations to fulfill their biological functions. Here we review recent concepts emerging from studies of protein folding in vitro and in vivo, with a focus on how proteins navigate the complex folding energy landscape inside cells with the aid of molecular chaperones. Understanding these reactions is also of considerable medical relevance, as the aggregation of misfolding proteins that escape the cellular quality-control machinery underlies a range of debilitating diseases, including many age-onset neurodegenerative disorders.}, author = {Hartl, F. Ulrich and Hayer-Hartl, Manajit}, citeulike-article-id = {4733200}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nsmb.1591}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nsmb.1591}, day = {03}, doi = {10.1038/nsmb.1591}, issn = {1545-9993}, journal = {Nature Structural \& Molecular Biology}, keywords = {in-vitro, in-vivo, protein-folding}, month = {June}, number = {6}, pages = {574--581}, posted-at = {2009-10-04 17:52:47}, priority = {2}, publisher = {Nature Publishing Group}, title = {Converging concepts of protein folding in vitro and in vivo}, url = {http://dx.doi.org/10.1038/nsmb.1591}, volume = {16}, year = {2009} }

TY - JOUR ID - citeulike:4733200 L3 - citeulike-article-id:4733200 N2 - Most proteins must fold into precise three-dimensional conformations to fulfill their biological functions. Here we review recent concepts emerging from studies of protein folding in vitro and in vivo, with a focus on how proteins navigate the complex folding energy landscape inside cells with the aid of molecular chaperones. Understanding these reactions is also of considerable medical relevance, as the aggregation of misfolding proteins that escape the cellular quality-control machinery underlies a range of debilitating diseases, including many age-onset neurodegenerative disorders. IS - 6 JF - Nature Structural & Molecular Biology SN - 1545-9993 EP - 581 TI - Converging concepts of protein folding in vitro and in vivo PB - Nature Publishing Group VL - 16 SP - 574 KW - in-vitro KW - in-vivo KW - protein-folding AU - Hartl, Ulrich AU - Hayer-Hartl, Manajit PY - 2009/06/03/ UR - http://dx.doi.org/10.1038/nsmb.1591 ER -