Predicting evolutionary patterns of mammalian teeth from development. Export

@article{citeulike:1746558, abstract = {One motivation in the study of development is the discovery of mechanisms that may guide evolutionary change. Here we report how development governs relative size and number of cheek teeth, or molars, in the mouse. We constructed an inhibitory cascade model by experimentally uncovering the activator-inhibitor logic of sequential tooth development. The inhibitory cascade acts as a ratchet that determines molar size differences along the jaw, one effect being that the second molar always makes up one-third of total molar area. By using a macroevolutionary test, we demonstrate the success of the model in predicting dentition patterns found among murine rodent species with various diets, thereby providing an example of ecologically driven evolution along a developmentally favoured trajectory. In general, our work demonstrates how to construct and test developmental rules with evolutionary predictability in natural systems.}, address = {Evolution \& Development Unit, Institute of Biotechnology, PO Box 56 (Viikinkaari 9), FIN-00014 University of Helsinki, Finland. kathryn\_kavanagh@yahoo.com}, author = {Kavanagh, Kathryn D. and Evans, Alistair R. and Jernvall, Jukka}, citeulike-article-id = {1746558}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature06153}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature06153}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17898761}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17898761}, day = {27}, doi = {10.1038/nature06153}, issn = {1476-4687}, journal = {Nature}, keywords = {08-smbe}, month = {September}, number = {7161}, pages = {427--432}, posted-at = {2008-06-02 18:08:15}, priority = {2}, title = {Predicting evolutionary patterns of mammalian teeth from development.}, url = {http://dx.doi.org/10.1038/nature06153}, volume = {449}, year = {2007} }

TY - JOUR ID - citeulike:1746558 L3 - citeulike-article-id:1746558 N2 - One motivation in the study of development is the discovery of mechanisms that may guide evolutionary change. Here we report how development governs relative size and number of cheek teeth, or molars, in the mouse. We constructed an inhibitory cascade model by experimentally uncovering the activator-inhibitor logic of sequential tooth development. The inhibitory cascade acts as a ratchet that determines molar size differences along the jaw, one effect being that the second molar always makes up one-third of total molar area. By using a macroevolutionary test, we demonstrate the success of the model in predicting dentition patterns found among murine rodent species with various diets, thereby providing an example of ecologically driven evolution along a developmentally favoured trajectory. In general, our work demonstrates how to construct and test developmental rules with evolutionary predictability in natural systems. IS - 7161 JF - Nature SN - 1476-4687 AD - Evolution & Development Unit, Institute of Biotechnology, PO Box 56 (Viikinkaari 9), FIN-00014 University of Helsinki, Finland. kathryn_kavanagh@yahoo.com EP - 432 TI - Predicting evolutionary patterns of mammalian teeth from development. VL - 449 SP - 427 KW - 08-smbe AU - Kavanagh, Kathryn AU - Evans, Alistair AU - Jernvall, Jukka PY - 2007/09/27/ UR - http://dx.doi.org/10.1038/nature06153 ER -