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Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.

by: Matthew D. Hirschey
Cell metabolism, Vol. 14, No. 6. (7 December 2011), pp. 718-719, doi:10.1016/j.cmet.2011.10.006  Key: citeulike:11297451

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Abstract

Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins. Copyright © 2011 Elsevier Inc. All rights reserved.


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