Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.
Seven mammalian sirtuins are nicotinamide adenine dinucleotide (NAD)(+)-dependent deacetylases and are important modulators of energy metabolism and stress resistance. Two new studies by Du et al. (2011) and Peng et al. (2011) identify a new enzymatic activity for SIRT5, expanding the cellular repertoire of posttranslational modifications targeted by the sirtuins. Copyright © 2011 Elsevier Inc. All rights reserved.